The effects of dietary food fortified with orotic acid (1.0%) on liver function were studied in rats. The rats fed with orotic acid promoted liver triglyceride content markedly, that was 5-fold higher than that of the control. The liver malondialdehyde (MDA) content increased by 10%, but the gluthation peroxidase (GSH-Px) activity decreased by 50%. The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities increased by 25% and 30%, respectively. Therefore, the decreased GSH-Px activity was associated with the promotions of AST, ALT, and the liver MDA levels. In conclusion: dietary orotic acid promotes lipid peroxidation but reduces the rate of the antioxidant enzyme. Therefore, dietary food fortified with orotic acid attenuates the liver function.
| Published by | Universitas Indonesia |
| Journal Name | MAKARA of Science Series |
| Contact Phone | - |
| Contact Name | - |
| Contact Email | - |
| Location | Kota depok, Jawa barat INDONESIA |
| Website | science| http://journal.ui.ac.id/index.php/science| |
| ISSN | ISSN : 23391995, EISSN : 23560851, DOI : 10.7454, |
| Core Subject | Science, |
| Meta Subject | Biochemistry, Genetics & Molecular Biology, Chemistry, Earth & Planetary Sciences, Materials Science & Nanotechnology, Physics, |
| Meta Desc | MAKARA Journal of Science publishes high quality research on fundamental science and provides a broad-based forum for the information sharing of ongoing research and development in science. Topics covered include physics, chemistry and biology. All submitted manuscripts will be subjected to the peer review process following a thorough inspection by the editors. Makara Journal of Science is the successor to the "MAKARA of Science Series" and "Makara Sains", which have been published since 1997. Starting from 2014, the journal has been periodically published four times a year (March, June, September, and December). |
| Penulis | Yohanes Buang |
| Publisher Article | Directorate of Research and Community Engagement, Universitas Indonesia |
| Subtitle Article | Makara Journal of Science Vol 15, No 2 (2011): November |
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