Genus of Alseodaphne has been known as a source of apoprhine alkaloid that displayed potent cytotoxic activities against selected cell lines. Two aporphine alkaloids, Corydine 1 and norlirioferine 2 were isolated from leaves of Alseodaphne peduncularis (Wall. Ex. Ness) Meissn. (Lauraceae). Phytochemical study involved extraction, separation and purification by using various chromatography methods and structural elucidation by using spectoscopic techniques such as UV, IR LC-MS and 1D and 2D NMR. These compounds were then assayed for cytotoxicity against human uteric cervical tumor (heLa) and compare for safety with normal mouse fibroblast (NIH/3T3) cell lines by using the MTT assay. Compound 2 displayed potent cytotoxic activities against heLa cell, but compound 1 showed as inactive. Both compounds have no significant effect against NIH/3T3 cell lines indicated good for cancer agent treatment.
| Published by | Universitas Islam Negeri Ar-Raniry Banda Aceh |
| Journal Name | CIRCUIT: Jurnal Ilmiah Pendidikan Teknik Elektro |
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| Location | Kota banda aceh, Aceh INDONESIA |
| Website | circuit| http://jurnal.ar-raniry.ac.id/index.php/circuit| |
| ISSN | ISSN : -, EISSN : -, DOI : -, |
| Core Subject | Education, Engineering, |
| Meta Subject | Education, Electrical & Electronics Engineering, Other, |
| Meta Desc | Journal Circuit is an Electrical Engineering Education Scientific journal which published by the Electrical Engineering Education Department, Faculty of Teaching and Training, Ar-Raniry State Islamic University, Banda Aceh. The Circuit Journal publishes empirical and theoretical contributions in the electrical engineering education scientific from the students, lecturers, professors or other scientists. The Circuit Journal manuscripts provide an original fundamental research, related to electrical engineering, electrical engineering education, and vocational education. The Circuit Journal also embossing the interpretative reviews, and discussion of new development in electrical engineering education |
| Penulis | Amna, Ulil , Ahmad, Kartini , Nafiah, Mohd Azlan |
| Publisher Article | PTE FTK UIN Ar-Raniry |
| Subtitle Article | CIRCUIT: Jurnal Ilmiah Pendidikan Teknik Elektro Vol 1, No 2 (2015) |
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| View Article | http://jurnal.ar-raniry.ac.id/… |
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Informasi yang terkait dengan Cytotoxic Activity of Aporphine Alkaloids from Alseodaphne Peduncularis (Wall. Ex. Ness) Meissn against Hela Cell Line