HIF1A

HIF1A
PDBに登録されている構造 PDB オルソログ検索: RCSB PDBe PDBj PDBのIDコード一覧 1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J
識別子
記号	HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α
外部ID	OMIM: 603348 MGI: 106918 HomoloGene: 1171 GeneCards: HIF1A
遺伝子の位置 (ヒト) 染色体 14番染色体 (ヒト)[1] バンド データ無し 開始点 61,695,513 bp[1] 終点 61,748,259 bp[1]
遺伝子の位置 (マウス) 染色体 12番染色体 (マウス)[2] バンド データ無し 開始点 73,948,149 bp[2] 終点 73,994,304 bp[2]
RNA発現パターン さらなる参照発現データ
遺伝子オントロジー 分子機能 • protein dimerization activity • DNA-binding transcription factor activity • DNA-binding transcription activator activity, RNA polymerase II-specific • ヒストンデアセチラーゼ結合 • 転写因子結合 • 酵素結合 • 血漿タンパク結合 • histone acetyltransferase binding • プロテインキナーゼ結合 • Hsp90タンパク質結合 • sequence-specific DNA binding • DNA結合 • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • ubiquitin protein ligase binding • protein heterodimerization activity • E-box binding • p53結合 • protein domain specific binding • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding 細胞の構成要素 • 細胞質 • 細胞質基質 • 細胞核 • nuclear speck • motile cilium • transcription regulator complex • RNA polymerase II transcription regulator complex • axon cytoplasm • 核質 • 核内構造体 • 高分子複合体 生物学的プロセス • negative regulation of neuron apoptotic process • B-1 B cell homeostasis • regulation of transforming growth factor beta2 production • muscle cell cellular homeostasis • outflow tract morphogenesis • negative regulation of ossification • heart looping • negative regulation of TOR signaling • 血管発生 • ヘモグロビン生合成プロセス • 血管新生 • positive regulation of chemokine-mediated signaling pathway • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of hormone biosynthetic process • negative regulation of mesenchymal cell apoptotic process • regulation of aerobic respiration • positive regulation of neuroblast proliferation • dopaminergic neuron differentiation • lactate metabolic process • regulation of transcription, DNA-templated • blood vessel morphogenesis • positive regulation of erythrocyte differentiation • glucose homeostasis • vascular endothelial growth factor production • regulation of thymocyte apoptotic process • positive regulation of epithelial cell migration • negative regulation of thymocyte apoptotic process • transcription, DNA-templated • positive regulation of transcription, DNA-templated • axonal transport of mitochondrion • positive regulation of macroautophagy • 軟骨形成 • positive regulation of nitric-oxide synthase activity • regulation of transcription from RNA polymerase II promoter in response to hypoxia • 授乳 • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • digestive tract morphogenesis • 細胞分化 • neural fold elevation formation • positive regulation of autophagy • retina vasculature development in camera-type eye • collagen metabolic process • embryonic placenta development • negative regulation of apoptotic process • positive regulation of angiogenesis • regulation of glycolytic process • 上皮間葉転換 • 大脳皮質発生 • 遺伝子発現調節 • positive regulation of chemokine production • intestinal epithelial cell maturation • 触媒活性調節 • positive regulation of autophagy of mitochondrion • cardiac ventricle morphogenesis • response to muscle activity • epithelial cell differentiation involved in mammary gland alveolus development • visual learning • positive regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of bone mineralization • negative regulation of growth • 低酸素症への反応 • positive regulation of endothelial cell proliferation • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • iris morphogenesis • mRNA transcription by RNA polymerase II • hypoxia-inducible factor-1alpha signaling pathway • 脈管構造発生 • regulation of cell population proliferation • neural crest cell migration • embryonic hemopoiesis • connective tissue replacement involved in inflammatory response wound healing • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • elastin metabolic process • positive regulation of glycolytic process • oxygen homeostasis • シグナル伝達 • positive regulation of transcription by RNA polymerase II • cellular iron ion homeostasis • camera-type eye morphogenesis • cellular response to hypoxia • cellular response to interleukin-1 • transcription by RNA polymerase II • protein deubiquitination • 翻訳後修飾 • response to iron ion • 遺伝子発現の負の調節 • positive regulation of blood vessel endothelial cell migration • positive regulation of gene expression • サイトカイン媒介シグナル伝達経路 • regulation of transcription by RNA polymerase II • protein ubiquitination 出典:Amigo / QuickGO
オルソログ
種	ヒト	マウス
Entrez	3091	15251
Ensembl	ENSG00000100644	ENSMUSG00000021109
UniProt	Q16665,D0VY79,A8MYV6	Q61221
RefSeq (mRNA)	NM_181054 NM_001243084 NM_001530	NM_010431 NM_001313919 NM_001313920
RefSeq (タンパク質)	NP_001230013 NP_001521 NP_851397 NP_001521.1	NP_001300848 NP_001300849 NP_034561
場所 (UCSC)	Chr 14: 61.7 – 61.75 Mb	Chr 14: 73.95 – 73.99 Mb
PubMed検索	[3]	[4]
ウィキデータ
閲覧/編集 ヒト 閲覧/編集 マウス

HIF1Aはヘテロ二量体として構成される低酸素誘導因子HIF-1のうちHIF-1αサブユニットをコードしている遺伝子。[5][6][7]

脚注

1. ^ GRCh38: Ensembl release 89: ENSG00000100644 - Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000021109 - Ensembl, May 2017
3. Human PubMed Reference:
4. Mouse PubMed Reference:
5. “Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q”. Genomics 34 (3): 437–9. (June 1996). doi:10.1006/geno.1996.0311. PMID 8786149. 
6. “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway”. J. Biol. Chem. 272 (13): 8581–93. (March 1997). doi:10.1074/jbc.272.13.8581. PMID 9079689. 
7. “Entrez Gene: HIF1A hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)”. 2017年10月10日閲覧。

参考文献

• “HIF-1 and human disease: one highly involved factor”. Genes Dev. 14 (16): 1983–91. (2000). PMID 10950862. 
• “Signal transduction to hypoxia-inducible factor 1”. Biochem. Pharmacol. 64 (5–6): 993–8. (2002). doi:10.1016/S0006-2952(02)01168-1. PMID 12213597. 
• “Quiescent hypervascularity mediated by gain of HIF-1 alpha function”. Cold Spring Harb. Symp. Quant. Biol. 67: 133–42. (2002). doi:10.1101/sqb.2002.67.133. PMID 12858534. 
• “Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors”. Nat. Rev. Immunol. 5 (9): 712–21. (2005). doi:10.1038/nri1685. PMID 16110315. 
• “Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes”. Histol. Histopathol. 20 (4): 1327–38. (2005). PMID 16136514. 
• “Hypoxia and HIF-1 alpha in chondrogenesis”. Semin. Cell Dev. Biol. 16 (4–5): 539–46. (2006). doi:10.1016/j.semcdb.2005.03.003. PMID 16144691. 
• “Hypoxia-inducible factors in the kidney”. Am. J. Physiol. Renal Physiol. 291 (2): F271-81. (2006). doi:10.1152/ajprenal.00071.2006. PMID 16554418. 
• “Effects of histone deacetylase inhibitors on HIF-1”. Cell Cycle 5 (21): 2430–5. (2006). doi:10.4161/cc.5.21.3409. PMID 17102633.