HDAC4

HDAC4
Domaine catalytique Hdac4. PDB2vqj
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S
Identifiants
Aliases	HDAC4
IDs externes	OMIM: 605314 MGI: 3036234 HomoloGene: 55946 GeneCards: HDAC4
Position du gène (Homme) Chr. Chromosome 2 humain[1] Locus 2q37.3 Début 239,048,168 bp[1] Fin 239,401,654 bp[1]
Position du gène (Souris) Chr. Chromosome 1 (souris)[2] Locus 1|1 D Début 91,856,501 bp[2] Fin 92,123,421 bp[2]
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans nerf sural muscle glutéal muscle gastrocnémien muscle tibial antérieur muscle de la cuisse muscle layer of sigmoid colon cellule endothéliale muscle deltoïde Skeletal muscle tissue of biceps brachii sang Fortement exprimé dans otic vesicle granulocyte gastrula Rostral migratory stream dentate gyrus of hippocampal formation granule cell muscle de la cuisse lèvre septum interventriculaire tissu musculaire skeletal muscle tissue Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire NAD-dependent histone deacetylase activity (H3-K14 specific) sequence-specific DNA binding liaison ADN transcription corepressor activity histone deacetylase activity zinc ion binding transcription factor binding liaison d'histone déacétylase potassium ion binding liaison de chromatine liaison ion métal liaison protéique protein kinase binding activité hydrolase protein deacetylase activity identical protein binding promoter-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding SUMO transferase activity Composant cellulaire cytoplasme histone deacetylase complex Plaque motrice transcription repressor complex Sarcomère Z discdkac A band actomyosin noyau cytosol nucléoplasme complexe macromoléculaire Processus biologique positive regulation of reactive oxygen species biosynthetic process histone H3 deacetylation skeletal system development Remodelage de la chromatine peptidyl-lysine deacetylation regulation of cardiac muscle contraction by calcium ion signaling negative regulation of glycolytic process response to interleukin-1 regulation of transcription, DNA-templated regulation of gene expression, epigenetic cellular response to tumor necrosis factor positive regulation of DNA-binding transcription factor activity negative regulation of transcription by RNA polymerase II positive regulation of protein sumoylation negative regulation of DNA-binding transcription factor activity negative regulation of osteoblast differentiation transcription, DNA-templated neurodéveloppement regulation of striated muscle cell differentiation régulation positive de la transcription dépendante de l'ADN positive regulation of smooth muscle cell migration B cell activation histone H4 deacetylation cellular response to mechanical stimulus positive regulation of neuron apoptotic process cardiac muscle hypertrophy in response to stress positive regulation of cell population proliferation negative regulation of myotube differentiation response to denervation involved in regulation of muscle adaptation regulation of skeletal muscle fiber development osteoblast development B cell differentiation cellular response to parathyroid hormone stimulus réponse inflammatoire positive regulation of lamellipodium assembly regulation of protein binding negative regulation of transcription, DNA-templated histone deacetylation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation positive regulation of smooth muscle cell proliferation organisation de la chromatine negative regulation of pri-miRNA transcription by RNA polymerase II protein deacetylation Sumoylation positive regulation of male mating behavior Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 9759 208727 Ensembl ENSG00000068024 ENSMUSG00000026313 UniProt P56524 Q6NZM9 RefSeq (mRNA) NM_006037 NM_001378414 NM_001378415 NM_001378416 NM_001378417 NM_207225 RefSeq (protéine) NP_006028 NP_001365343 NP_001365344 NP_001365345 NP_001365346 NP_997108 Localisation (UCSC) Chr 2: 239.05 – 239.4 Mb Chr 1: 91.86 – 92.12 Mb Publication PubMed [3] [4]
Wikidata
Voir/Editer Humain Voir/Editer Souris

L'HDAC4 est une histone désacétylase. Son gène est le HDAC4 situé sur le chromosome 2 humain.

Rôles

Elle appartient à la classe II des histones désacétylases.

La protéine est phophorylée par le CaMKII qui en modifie l'activité[5], entraînant par exemple une hypertrophie des cardiomyocytes[6]. Elle contrôle également la prolifération et la migration des cellules musculaires lisses[7] contribuant ainsi à la genèse d'une hypertension artérielle[8].

Elle régule l'autophagie induite par l'angiotensine 2[9].

Notes et références

1. GRCh38: Ensembl release 89: ENSG00000068024 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026313 - Ensembl, May 2017
3. « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
4. « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
5. Dokmanovic M, Clarke C, Marks PA, Histone deacetylase inhibitors: overview and perspectives, Mol Cancer Res, 2007;5:981–989
6. Backs J, Song K, Bezprozvannaya S, Chang S, Olson EN, CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy, J Clin Invest, 2006;116:1853–1864
7. Usui T, Morita T, Okada M, Yamawaki H, Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells, Hypertension, 2014;63:397
8. Usui T, Okada M, Mizuno W, Oda M, Ide N, Morita T, Hara Y, Yamawaki H, HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats, Am J Physiol-Heart C, 2012;302:H1894–H1904
9. Yang D, Xiao C, Long F et al. HDAC4 regulates vascular inflammation via activation of autophagy, Cardiovascular Research, 2018;114:1016–1028