Volociximab

Volociximab
Monoclonal antibody
TypeWhole antibody
SourceChimeric (mouse/human)
Targetα5β1 integrin
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6434H9942N1706O2040S52
Molar mass145501.33 g·mol−1
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Volociximab (also known as M200) is a chimeric monoclonal antibody jointly developed by PDL BioPharma and Biogen Idec for treatment of a variety of advanced solid tumors. It binds to and inhibits the functional activity of α5β1 integrin.[1]

It is thought to reduce metastases. Early results show potential in renal cell cancers.[citation needed]

References

  1. ^ Ng CM, Bai S, Takimoto CH, Tang MT, Tolcher AW (January 2010). "Mechanism-based receptor-binding model to describe the pharmacokinetic and pharmacodynamic of an anti-α5β1 integrin monoclonal antibody (volociximab) in cancer patients". Cancer Chemotherapy and Pharmacology. 65 (2): 207–17. doi:10.1007/s00280-009-1023-8. PMID 19468731. S2CID 23035675.
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