Indium (111In) biciromab

Indium (^111In) biciromab

Monoclonal antibody
Type	Fab' fragment
Source	Mouse
Target	Fibrin II, beta chain
Clinical data
Trade names	FibriScint
Pregnancy category	N/A
ATC code	none
Legal status
Legal status	Withdrawn
Identifiers
CAS Number	138783-13-8^N
ChemSpider	none
KEGG	D03111^Y
^NY (what is this?)  (verify)

Indium (^111In) biciromab (INN, trade name FibriScint, developed by Centocor) was a drug targeting fibrin, a protein involved in the clotting of blood.[1] It was the Fab' fragment of a mouse monoclonal antibody labelled with the radioisotope indium-111 for the diagnosis of thromboembolism,[2] but was withdrawn during clinical trials.[3]

References

1. King DJ, Adair JR (March 1999). "Recombinant antibodies for the diagnosis and therapy of human diseases". Current Opinion in Drug Discovery & Development. 2 (2): 110–7. PMID 19649936.
2. "Centocor Ortho Biotech Products, L.P." Answers.com.
3. "Centocor withdraws imaging agent applications". DiagnosticImaging.com.