Before the U.S. Route system was established in 1926, the road that became US 25 was mostly numbered as State Route 6 (SR 6), but was numbered as SR 28 and SR 124 in the Cincinnati area.[3] The route that became US 25 was also part of the eastern leg of the Dixie Highway. In 1950s and 1960s, US 25 was transferred to a new freeway that was the basis for I-75.[4] Nearly all of the original road remains intact, however, still named Dixie Highway in some parts, and with some segments given county highway designations of CR-25A.
In 1973, the route was decommissioned in Ohio and Michigan due to its redundancy with Interstate highways. From Cygnet northward, the independent routing of US 25, up to its concurrency with US 24 at the intersection of Detroit Avenue and Cherry Street, became the whole of SR 25. The former concurrency to Telegraph Road retained the US 24 designation, while the remaining segment of Detroit Avenue northward to the state line was decommissioned as a state highway, continuing into Michigan as M-125/Dixie Highway. In 1986, the segment of SR 25 along Detroit Avenue was swapped with US 24, with the state route taking a new alignment from downtown Toledo to I-280.[5]
Now Closed; southbound originally had two ramps to Riverside Drive which were later removed; access consolidated with newly built Main Street exit as part of I-75 Downtown Modernization[11]
Now Closed; was signed northbound as exits 55A (Keowee Street south) and 55B (Keowee Street north, Leo Street); access to Keowee consolidated with Webster Street as part of I-75 Downtown Modernization[11]
Former northbound exit and southbound entrance; closed with I-75 Downtown Modernization[11]
56.74
91.31
44
57B
Wagner Ford Road, Siebenthaler Avenue, Neff Road
Neff Road signed southbound only; southbound exit ramp connects to Neff Road, Keats Drive, and a traffic circle which connects to Wagner Ford Road and Dixie Drive.
58.21
93.68
45
58
Needmore Road
60.71
97.70
46
60
Little York Road
Now Closed; northbound access was via Poe Avenue and southbound access via Miller Lane; replaced by exit 59
^Office of Technical Services (January 1, 2007). "Straight Line Diagrams". Ohio Department of Transportation. Archived from the original on February 19, 2003.
^Ohio Department of Highways (1969). Official Highway Map(PDF) (Map). c. 1:563,200. Columbus: Ohio Department of Highways. OCLC5673562, 7448779. Retrieved June 17, 2018.
^Ohio Department of Transportation (1976). Ohio Transportation Map(PDF) (Map). Scale not given. Columbus: Ohio Department of Transportation. Cincinnati inset. OCLC5673562, 13655720, 35168139. Retrieved June 17, 2018.
^Ohio Department of Highways (1967). Official Highway Map(PDF) (Map). c. 1:563,200. Columbus: Ohio Department of Highways. § E6. OCLC5673562, 7444249. Retrieved June 17, 2018.
^Ohio Department of Highways (1969). Official Highway Map(PDF) (Map). c. 1:563,200. Columbus: Ohio Department of Highways. § E6. OCLC5673562, 7448779. Retrieved June 17, 2018.
^Ohio Department of Transportation (1973). Ohio Transportation Map(PDF) (Map). 1:554,400. Columbus: Ohio Department of Transportation. § E6. OCLC5673562. Retrieved June 17, 2018.
^Ohio Department of Transportation (1974). Ohio Transportation Map(PDF) (Map). 1:554,400. Columbus: Ohio Department of Transportation. § E6. OCLC5673562. Retrieved June 17, 2018.
^Ohio Department of Highways (1969). Official Highway Map(PDF) (Map). c. 1:563,200. Columbus: Ohio Department of Highways. OCLC5673562, 7448779. Retrieved June 17, 2018.