Tryptophan alpha,beta-oxidase

tryptophan alpha,beta-oxidase
Identifiers
EC no.	1.3.3.10
CAS no.	156859-19-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a tryptophan alpha,beta-oxidase (EC 1.3.3.10) is an enzyme that catalyzes the chemical reaction

L-tryptophan + O₂ ${\displaystyle \rightleftharpoons }$ alpha,beta-didehydrotryptophan + H₂O₂

Thus, the two substrates of this enzyme are L-tryptophan and O₂, whereas its two products are alpha,beta-didehydrotryptophan and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is L-tryptophan:oxygen alpha,beta-oxidoreductase. Other names in common use include L-tryptophan 2',3'-oxidase, and L-tryptophan alpha,beta-dehydrogenase. It employs one cofactor, heme.

References

• Genet R, Denoyelle C, Menez A (1994). "Purification and partial characterization of an amino acid alpha,beta- dehydrogenase, L-tryptophan 2',3'-oxidase from Chromobacterium violaceum". J. Biol. Chem. 269 (27): 18177–84. PMID 8027079.
• Genet R, Benetti PH, Hammadi A, Menez A (1995). "L-tryptophan 2',3'-oxidase from Chromobacterium violaceum. Substrate specificity and mechanistic implications". J. Biol. Chem. 270 (40): 23540–5. doi:10.1074/jbc.270.40.23540. PMID 7559518.