TECTA

TECTA
Identifiers
Aliases	TECTA, DFNA12, DFNA8, DFNB21, tectorin alpha
External IDs	OMIM: 602574; MGI: 109575; HomoloGene: 3955; GeneCards: TECTA; OMA:TECTA - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	121,191,490 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	42,311,225 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; testicle; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; superior vestibular nucleus; ; pons; ; Brodmann area 23; ; ventricular zone;
	Top expressed in
	vestibular sensory epithelium; ; utricle; ; saccule; ; lumbar spinal ganglion; ; epithelium of macula of saccule of membranous labyrinth; ; petrous part of the temporal bone; ; cochlea; ; epithelium of macula of utricle of membranous labyrinth; ; embryo; ; entorhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent;
Cellular component	anchored component of membrane; extracellular exosome; membrane; extracellular region; plasma membrane; extracellular matrix; collagen-containing extracellular matrix;
Biological process	cell-matrix adhesion; hearing; C-terminal protein lipidation;
	Sources:Amigo / QuickGO
Orthologs
	7007
	21683
	ENSG00000109927
	ENSMUSG00000037705
	O75443
	O08523
	NM_005422
	NM_009347; NM_001324548; NM_001378602
	NP_005413
	NP_001311477; NP_033373; NP_001365531
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-tectorin is a protein that in humans is encoded by the TECTA gene.^[5]^[6]^[7]

The tectorial membrane is an apical extracellular matrix (aECM) of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109927 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037705 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hughes DC, Legan PK, Steel KP, Richardson GP (Apr 1998). "Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness". Genomics. 48 (1): 46–51. doi:10.1006/geno.1997.5159. PMID 9503015.
^ Verhoeven K, Van Laer L, Kirschhofer K, Legan PK, Hughes DC, Schatteman I, Verstreken M, Van Hauwe P, Coucke P, Chen A, Smith RJ, Somers T, Offeciers FE, Van de Heyning P, Richardson GP, Wachtler F, Kimberling WJ, Willems PJ, Govaerts PJ, Van Camp G (May 1998). "Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment". Nat Genet. 19 (1): 60–2. doi:10.1038/ng0598-60. PMID 9590290. S2CID 24814696.
^ ^a ^b "Entrez Gene: TECTA tectorin alpha".