The S in ISEA refers to John P. Snyder. He came out of retirement specifically to address projection problems with the original EMAP grid (see Snyder, 1992). He developed the equal area projection that underlies the gridding system.
ISEA grids are simple in concept. Begin with a Snyder Equal Area projection to a regular icosahedron (...) inscribed in a sphere. In each of the 20 equilateral triangle faces of the icosahedron inscribe a hexagon by dividing each triangle edge into thirds (...). Then project the hexagon back onto the sphere using the Inverse Snyder Icosahedral equal area projection. This yields a coarse-resolution equal area grid called the resolution 1 grid. It consists of 20 hexagons on the surface of the sphere and 12 pentagons centered on the 12 vertices of the icosahedron.