SSH3

SSH3
Identifiers
Aliases	SSH3, SSH3L, slingshot protein phosphatase 3
External IDs	OMIM: 606780; MGI: 2683546; HomoloGene: 32372; GeneCards: SSH3; OMA:SSH3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 67,303,478 bp[1] End 67,312,607 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 4,311,696 bp[2] End 4,319,208 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right hemisphere of cerebellum minor salivary glands right uterine tube mucosa of transverse colon vagina skin of leg ectocervix skin of abdomen gastric mucosa Top expressed in granulocyte lip esophagus primary visual cortex superior frontal gyrus cerebellar cortex stomach colon neural layer of retina duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity actin binding phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity Cellular component cytoplasm cytoskeleton nucleus Biological process regulation of lamellipodium assembly regulation of axonogenesis regulation of actin polymerization or depolymerization protein dephosphorylation peptidyl-tyrosine dephosphorylation dephosphorylation cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54961 245857 Ensembl ENSG00000172830 ENSMUSG00000034616 UniProt Q8TE77 Q8K330 RefSeq (mRNA) NM_017857 NM_018276 NM_198113 NM_001356620 NM_001374687 RefSeq (protein) NP_060327 NP_932781 NP_001343549 Location (UCSC) Chr 11: 67.3 – 67.31 Mb Chr 19: 4.31 – 4.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.[5][6]

Function

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000172830 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034616 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208.
6. "Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)".

Further reading

• Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC (November 2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes". The Journal of Biological Chemistry. 282 (44): 32520–8. doi:10.1074/jbc.M707041200. PMC 2754063. PMID 17848544.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O (February 2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". The EMBO Journal. 24 (3): 473–86. doi:10.1038/sj.emboj.7600543. PMC 548651. PMID 15660133.
• Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K (October 2003). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". Genes to Cells. 8 (10): 811–24. doi:10.1046/j.1365-2443.2003.00678.x. PMID 14531860. S2CID 24247372.