Formerly as M21, it was part of the Soviet trunk road network and started from Chișinău via Dnipro to Volgograd. In 2010 the section in Russia received the number A260, but the M21 designation was used until the end of 2017, when the A260 designation became official.[1] The entire route is part of E40 and AH70.
In July 2023, as a part of their annexation works of Luhansk People's Republic that de-facto controlled city of Luhansk for nearly 10 years, the previous A260 highway has extended to Luhansk, and renamed the number to R260.[2]
