Mavorixafor

Mavorixafor
Clinical data
Trade namesXolremdi
Other namesX4P-001; AMD-070
AHFS/Drugs.comMultum Consumer Information
License data
Routes of
administration		By mouth
Drug classCXCR4 antagonist
ATC code
  • None
Legal status
Legal status
Identifiers
  • N′-(1H-Benzimidazol-2-ylmethyl)-N′-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H27N5
Molar mass349.482 g·mol−1
3D model (JSmol)
  • C1C[C@@H](C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3
  • InChI=1S/C21H27N5/c22-12-3-4-14-26(15-20-24-17-9-1-2-10-18(17)25-20)19-11-5-7-16-8-6-13-23-21(16)19/h1-2,6,8-10,13,19H,3-5,7,11-12,14-15,22H2,(H,24,25)/t19-/m0/s1
  • Key:WVLHHLRVNDMIAR-IBGZPJMESA-N

Mavorixafor, sold under the brand name Xolremdi, is a medication used for the treatment of WHIM syndrome.[1] It is a CXC chemokine receptor 4 antagonist.[1] It is taken by mouth.[1] It was developed by X4 Pharmaceuticals.

The most frequently reported adverse reactions include thrombocytopenia (low platelet counts), rash, rhinitis (stuffy nose), epistaxis (nosebleed), vomiting, and dizziness.[2]

Mavorixafor was approved for medical use in the United States in April 2024.[1][2][3][4]

Medical uses

Mavorixafor is indicated in people twelve years of age and older with WHIM syndrome (warts, hypogammaglobulinemia, infections and myelokathexis) to increase the number of circulating mature neutrophils and lymphocytes.[1][2]

Adverse effects

Mavorixafor is expected to cause harm to the baby.[1][2]

History

The effectiveness of mavorixafor was evaluated in a 52-week, randomized, double-blind, placebo-controlled trial that enrolled 31 adolescents and adults with WHIM syndrome (NCT03995108).[2] Mavorixafor improved absolute neutrophil counts and absolute lymphocyte counts, assessed over a 24-hour period four times throughout the study.[2] Absolute neutrophil counts below 500 cells/μL and absolute lymphocyte counts below 1000 cells/μL are associated with an increased risk of infections.[2] The average length of time over 24 hours that counts were above these levels was significantly longer with mavorixafor compared to the placebo group (15.0 hours compared to 2.8 hours for absolute neutrophil counts; 15.8 hours compared to 4.6 hours for absolute lymphocyte counts).[2]

Society and culture

Names

Mavorixafor is the international nonproprietary name.[5]

Research

Mavorixafor is in clinical trials for melanoma[6] and renal cell carcinoma.[7]

References

  1. ^ a b c d e f g "Xolremdi- mavorixafor capsule, gelatin coated". DailyMed. 4 June 2024. Retrieved 16 June 2024.
  2. ^ a b c d e f g h "FDA approves first drug for WHIM syndrome, a rare disorder". U.S. Food and Drug Administration (FDA). 29 April 2024. Archived from the original on 29 April 2024. Retrieved 29 April 2024. Public Domain This article incorporates text from this source, which is in the public domain.
  3. ^ "Novel Drug Approvals for 2024". U.S. Food and Drug Administration (FDA). 29 April 2024. Archived from the original on 30 April 2024. Retrieved 30 April 2024.
  4. ^ "X4 Pharmaceuticals Announces FDA Approval of Xolremdi (mavorixafor) Capsules, First Drug Indicated in Patients with WHIM Syndrome" (Press release). X4 Pharmaceuticals. 29 April 2024. Archived from the original on 29 April 2024. Retrieved 29 April 2024 – via GlobeNewswire.
  5. ^ World Health Organization (2018). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 80". WHO Drug Information. 32 (3). hdl:10665/330907.
  6. ^ Andtbacka, Robert H.I.; Wang, Yan; Pierce, Robert H.; Campbell, Jean S.; Yushak, Melinda; Milhem, Mohammed; et al. (31 August 2022). "Mavorixafor, an Orally Bioavailable CXCR4 Antagonist, Increases Immune Cell Infiltration and Inflammatory Status of Tumor Microenvironment in Patients with Melanoma". Cancer Research Communications. 2 (8): 904–913. doi:10.1158/2767-9764.CRC-22-0090. PMC 10010370. PMID 36923305.
  7. ^ Choueiri, Toni K.; Atkins, Michael B.; Rose, Tracy L.; Alter, Robert S.; Ju, Yawen; Niland, Katie; et al. (August 2021). "A phase 1b trial of the CXCR4 inhibitor mavorixafor and nivolumab in advanced renal cell carcinoma patients with no prior response to nivolumab monotherapy". Investigational New Drugs. 39 (4): 1019–1027. doi:10.1007/s10637-020-01058-2. PMID 33507454. S2CID 231746027.
  • Clinical trial number NCT03995108 for "Efficacy and Safety Study of Mavorixafor in Participants With Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome" at ClinicalTrials.gov