KCNG3

KCNG3
Identifiers
Aliases	KCNG3, KV10.1, KV6.3, potassium voltage-gated channel modifier subfamily G member 3
External IDs	OMIM: 606767; MGI: 2663923; HomoloGene: 15168; GeneCards: KCNG3; OMA:KCNG3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 42,442,017 bp[1] End 42,493,982 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 83,893,386 bp[2] End 83,939,324 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans prefrontal cortex right adrenal gland left adrenal gland right adrenal cortex middle temporal gyrus endometrium left adrenal cortex Brodmann area 23 entorhinal cortex Top expressed in secondary oocyte zygote primary oocyte epiblast dentate gyrus of hippocampal formation granule cell embryo adrenal gland hippocampus proper ovary Cortex of frontal lobe More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated potassium channel activity ion channel activity potassium channel activity protein binding delayed rectifier potassium channel activity voltage-gated ion channel activity Cellular component cytoplasm integral component of membrane voltage-gated potassium channel complex plasma membrane endoplasmic reticulum membrane Biological process potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 170850 225030 Ensembl ENSG00000171126 ENSMUSG00000045053 UniProt Q8TAE7 P59053 RefSeq (mRNA) NM_172344 NM_133329 NM_153512 RefSeq (protein) NP_579875 NP_758847 NP_705732 Location (UCSC) Chr 2: 42.44 – 42.49 Mb Chr 17: 83.89 – 83.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily G member 3 is a protein that in humans is encoded by the KCNG3 gene.[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000171126 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045053 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sano Y, Mochizuki S, Miyake A, Kitada C, Inamura K, Yokoi H, Nozawa K, Matsushime H, Furuichi K (Feb 2002). "Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1". FEBS Lett. 512 (1–3): 230–4. doi:10.1016/S0014-5793(02)02267-6. PMID 11852086. S2CID 83987133.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

Further reading

• Mederos Y, Schnitzler M, Rinné S, Skrobek L, et al. (2009). "Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4". J. Biol. Chem. 284 (7): 4695–704. doi:10.1074/jbc.M808786200. PMID 19074135.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7986–91. Bibcode:2002PNAS...99.7986O. doi:10.1073/pnas.122617999. PMC 123007. PMID 12060745.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vega-Saenz de Miera EC (2004). "Modification of Kv2.1 K+ currents by the silent Kv10 subunits". Brain Res. Mol. Brain Res. 123 (1–2): 91–103. doi:10.1016/j.molbrainres.2004.01.004. PMID 15046870.

External links

• Kv6.3+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNG3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)