CLCA3

CLCA3P
Identifiers
Aliases	CLCA3P, CLCA3, chloride channel accessory 3, pseudogene
External IDs	OMIM: 604337; GeneCards: CLCA3P; OMA:CLCA3P - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 86,634,273 bp[1] End 86,655,376 bp[1]
Gene ontology Molecular function voltage-gated ion channel activity chloride channel activity calcium channel activity transporter activity metalloendopeptidase activity Cellular component extracellular region plasma membrane chloride channel complex extracellular space Biological process calcium ion transport ion transmembrane transport regulation of ion transmembrane transport chloride transport chloride transmembrane transport ion transport calcium ion transmembrane transport proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9629 n/a Ensembl ENSG00000153923 n/a UniProt Q9Y6N3 n/a RefSeq (mRNA) NM_004921 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 1: 86.63 – 86.66 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Chloride channel accessory 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene. The protein encoded by this gene is a chloride channel.[3] According to the HGNC, this protein is not expressed in humans but is in certain other species such as mouse. However, some conflicting reports state that human cells produce and glycosylate this protein.[3]

Function

This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD), although this gene is translated into a well characterized protein which has been shown to decorate mucin granule containing vesicles. Protein structure prediction methods suggest the N-terminal region of CLCA3 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[4]

See also

• Chloride channel

References

1. GRCh38: Ensembl release 89: ENSG00000153923 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Gruber AD, Pauli BU (March 1999). "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels". Biochimica et Biophysica Acta. 1444 (3): 418–23. doi:10.1016/S0167-4781(99)00008-1. PMID 10095065.
4. Pawłowski K, Lepistö M, Meinander N, Sivars U, Varga M, Wieslander E (May 2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

Further reading

• Liu QH, Williams DA, McManus C, Baribaud F, Doms RW, Schols D, et al. (April 2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proceedings of the National Academy of Sciences of the United States of America. 97 (9): 4832–7. Bibcode:2000PNAS...97.4832L. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
• Pauli BU, Abdel-Ghany M, Cheng HC, Gruber AD, Archibald HA, Elble RC (November 2000). "Molecular characteristics and functional diversity of CLCA family members". Clinical and Experimental Pharmacology & Physiology. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307. S2CID 28762005.
• Gruber AD, Pauli BU (October 1999). "Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31)". Genome. 42 (5): 1030–2. doi:10.1139/gen-42-5-1030. PMID 10584316.

External links

• CLCA3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.