Daf-4

abnormal dauer formation protein 4
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-4
Entrez175781
HomoloGene124563
UniProtP50488
Other data
ChromosomeIII: 5.63 - 5.63 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The DAF-4 gene encodes for the only type II receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans,[1] with the ligands Daf-7 or Dbl-1.[2] When binds to the ligand Daf-7, Daf-4 complexed with the type I receptor Daf-1, and activated the Smad Protein Daf-8/14. By contrast, when binds to Dbl-1, Daf-4 complexed with the Sma-6 type I receptor, and activated the Sma-2/3/4.[3]

References

  1. ^ Morita K, Shimizu M, Shibuya H, Ueno N (May 2001). "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6284–8. Bibcode:2001PNAS...98.6284M. doi:10.1073/pnas.111409798. PMC 33460. PMID 11353865.
  2. ^ Savage C, Das P, Finelli AL, Townsend SR, Sun CY, Baird SE, Padgett RW (January 1996). "Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components". Proceedings of the National Academy of Sciences of the United States of America. 93 (2): 790–4. Bibcode:1996PNAS...93..790S. doi:10.1073/pnas.93.2.790. PMC 40134. PMID 8570636.
  3. ^ Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". Development. 126 (2): 251–60. doi:10.1242/dev.126.2.251. PMID 9847239. S2CID 2460114.


Read other articles:

Large numeric or alphanumeric display used to convey information Tote Board at Hollywood Park, California A tote board (or totalisator/totalizator) is a numeric or alphanumeric display used to convey information, typically at a race track (to display the odds or payoffs for each horse) or at a telethon (to display the total amount donated to the charitable organization sponsoring the event). The term tote board comes from the colloquialism for totalizator (or totalisator), the name for the autom…

Miosen23.03 ± 0.3 – 5.333 ± 0.08 Ma PreЄ Є O S D C P T J K Pg N Kronologi Sistem/Periode Seri/Kala Masa/Usia Penanggalan mutlak (Ma) Kuarter Pleistosen Gelasium younger Neogen Pliosen Piacenzium 2.58 3.600 Zankleum 3.600 5.333 Miosen Messinium 5.333 7.246 Tortonium 7.246 11.63 Serravalium 11.63 13.82 Langhium 13.82 15.97 Burdigalium 15.97 20.44 Aquitanium 20.44 23.03 Paleogen Oligosen Chattium older Subdivisi Periode Neogen menurut ICS, pada Januari 2017.[1] EtimologiNama resmiForm…

Armata del James Army of the Jamesil quartier generale dell'Armata del James in un dipinto Descrizione generaleAttivaaprile 1864 - agosto 1865 Nazione Unione Servizio Union Army TipoArmata Battaglie/guerreGuerra di secessione americana ComandantiComandantiBenjamin F. Butler (1864-1865) Edward Ord (1865) Voci su unità militari presenti su Wikipedia L'Armata del James fu un'unità militare dell'esercito dell'Unione, composta da unità minori provenienti dal Dipartimento Militare della Virginia e …

Questa voce o sezione sull'argomento compositori francesi non cita le fonti necessarie o quelle presenti sono insufficienti. Puoi migliorare questa voce aggiungendo citazioni da fonti attendibili secondo le linee guida sull'uso delle fonti. Alexandre Clément Léon Joseph Luigini Alexandre Clément Léon Joseph Luigini (Lione, 9 marzo 1850 – Parigi, 29 luglio 1906) è stato un compositore e direttore d'orchestra francese. Biografia I suoi nonni giunsero a Lione da Modena nel 1832, quando …

Pour les articles homonymes, voir Concile de Nicée. Premier concile de Nicée L'empereur Constantin (au centre), avec les évêques du concile de Nicée (325), tenant anachroniquement le texte du « symbole de Nicée-Constantinople » dans sa forme liturgique grecque fondée sur le texte adopté au premier concile de Constantinople (381 apr. J.-C.) Informations générales Début 20 mai 325 Fin 25 juillet 325 Lieu Nicée Liste des conciles Premier concile de Constantinople modifier…

Family of flowering plants in the order Saxifragales Peridiscaceae Botanical illustration of Peridiscus lucidus Scientific classification Kingdom: Plantae Clade: Tracheophytes Clade: Angiosperms Clade: Eudicots Order: Saxifragales Family: PeridiscaceaeKuhlm.[1] Type genus PeridiscusBenth. Genera Medusandra Brenan Peridiscus Benth. Soyauxia Oliv. Whittonia Sandwith Peridiscaceae is a family of flowering plants in the order Saxifragales.[2] Four genera comprise this family: Medusan…

Voulangis La mairie. Héraldique Administration Pays France Région Île-de-France Département Seine-et-Marne Arrondissement Meaux Intercommunalité Communauté d'agglomération Coulommiers Pays de Brie Maire Mandat Franz Molet 2020-2026 Code postal 77580 Code commune 77529 Démographie Gentilé Voulangeois Populationmunicipale 1 499 hab. (2021 ) Densité 156 hab./km2 Géographie Coordonnées 48° 51′ 05″ nord, 2° 53′ 57″ est Altitude Min. 4…

BukkumiSusu-bukkumi (kue sorgum goreng)JenisTteokTempat asalKoreaMasakan nasional terkaitHidangan KoreaSunting kotak info • L • BBantuan penggunaan templat ini  Media: Bukkumi Korean nameHangul부꾸미 Alih AksarabukkumiMcCune–ReischauerpukkumiIPA[pu.k͈u.mi] Bukkumi (부꾸미) adalah tteok (kue beras) goreng yang dibuat dengan tepung ketan atau tepung sorgum.[1] Ini adalah kue pipih berbentuk setengah bulan yang diisi dengan pasta kacang adzuki putih atau…

Danish football club Football clubLystrup IFFull nameLystrup IdrætsforeningNickname(s)LIFFounded20 February 1934; 90 years ago (1934-02-20)[1]GroundLystrup IdrætsanlægLystrup, AarhusCapacity200LeagueDBU Jyllands Serie 3WebsiteClub website Home colours Lystrup Idrætsforening is a Danish association football club currently playing in the DBU Jyllands Serie 3, one of the ninth tiers of Danish football. They play at Lystrup Idrætsanlæg in Lystrup, East Jutland. Histor…

2008 video game 2008 video gameRagnarok DSNorth American cover artDeveloper(s)TosePublisher(s)JP: GungHo Online EntertainmentKOR: GravityNA: Xseed GamesDesigner(s)Masayuki MorimotoSeriesRagnarok seriesPlatform(s)Nintendo DSReleaseJP: December 18, 2008KR: June 25, 2009NA: February 16, 2010Genre(s)Role-playingMode(s)Single-player, multiplayer, online multiplayer Ragnarok DS, known in Japan as Ragnarok Online DS (ラグナロクオンラインDS, Ragunaroku Onrain Dī Esu), is a Nintendo DS video g…

Mountain in Canada Coquitlam MountainView from Burke Mountain on the southern ridge of Coquitlam Mountain.Highest pointElevation1,583 m (5,194 ft)[1]Prominence698 m (2,290 ft)[1]Coordinates49°23′34″N 122°42′25″W / 49.39278°N 122.70694°W / 49.39278; -122.70694[2]GeographyLocationCoquitlam, British ColumbiaDistrictNew Westminster Land DistrictParent rangePacific RangesTopo mapNTS 92G7 Port Coquitlam[2]…

Ongoing COVID-19 viral pandemic in Greece COVID-19 pandemic in GreeceDiseaseCOVID-19Virus strainSARS-CoV-2LocationGreeceFirst outbreakWuhan, Hubei, ChinaIndex caseThessalonikiArrival date26 February 2020(4 years, 3 months, 3 weeks and 1 day)Confirmed cases5,637,195[1]Recovered6,064,290 reported[2]Deaths39,022[1]Fatality rate0.69%Vaccinations7,938,006[1] (total vaccinated)7,647,073[1] (fully vaccinated)22,467,833[1] (doses admini…

Etil iodida Model bola dan tongkat etil iodida Model ruang terisi etil iodida Nama Nama IUPAC Iodoetana[1] Penanda Nomor CAS 75-03-6 Y Model 3D (JSmol) Gambar interaktif 3DMet {{{3DMet}}} Referensi Beilstein 505934 ChEBI CHEBI:42487 N ChEMBL ChEMBL1232588 N ChemSpider 6100 Y Nomor EC PubChem CID 6340 Nomor RTECS {{{value}}} CompTox Dashboard (EPA) DTXSID9058783 InChI InChI=1S/C2H5I/c1-2-3/h2H2,1H3 YKey: HVTICUPFWKNHNG-UHFFFAOYSA-N Y SMILES CCI Sifat Rum…

السباحة في الألعاب الأولمبية الصيفية 2016 في الألعاب الأولمبية الصيفية تعديل مصدري - تعديل   عقدت منافسات السباحة في دورة الألعاب الأولمبية الصيفية 2016 في ريو دي جانيرو في الفترة من 06-13 أغسطس في الاستاد الاولمبي للرياضات المائية . وعقدت منافسات سباق الماراثون في المياه المفت…

Artikel ini perlu dikembangkan agar dapat memenuhi kriteria sebagai entri Wikipedia.Bantulah untuk mengembangkan artikel ini. Jika tidak dikembangkan, artikel ini akan dihapus. Staffordshire county seremonial di Inggris Staffordshire tanpa nilai Tempat Negara berdaulatBritania RayaNegara konstituen di Britania RayaInggrisRegion di InggrisWest Midlands NegaraBritania Raya Ibu kotaStafford Pembagian administratifStaffordshire (en) City of Stoke-on-Trent (en) PendudukTotal1.139.794  (2020 )Geo…

هذه المقالة تحتاج للمزيد من الوصلات للمقالات الأخرى للمساعدة في ترابط مقالات الموسوعة. فضلًا ساعد في تحسين هذه المقالة بإضافة وصلات إلى المقالات المتعلقة بها الموجودة في النص الحالي. (مارس 2018) هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إلي…

عبد الله بن عبد المطلب الكنية أبو مُحمَّد الولادة 79 ق.هـ / 544 - 545ممكة، شبه الجزيرة العربية الوفاة 54 ق.هـ / 570م (25 سنة)يثرب، شبه الجزيرة العربية مكان الدفن دار النابغة، يثرب[1] الزوج(ة) آمنة بنت وهب النسب أبوه: عبد المطلب بن هاشم بن عبد منافأمه: فاطمة بنت عمرو المخزومية إخوته: ال…

Disambiguazione – Se stai cercando altri significati, vedi Mark Phillips (disambigua). Mark PhillipsMark Phillips nel 1980Nazionalità Regno Unito Altezza185 cm Peso79 kg Equitazione Palmarès Competizione Ori Argenti Bronzi Giochi olimpici 1 1 0 Mondiali 1 1 0 Europei 1 0 0 Vedi maggiori dettagli  Modifica dati su Wikidata · Manuale Mark Anthony Peter Phillips (Cirencester, 22 settembre 1948) è un cavaliere ed ex atleta britannico, vincitore della medaglia d'oro nel concorso …

Forgotten Realms novel Gauntlgrym Cover of the first editionAuthorR. A. SalvatoreCover artistTodd LockwoodLanguageEnglishSeriesNeverwinter SagaGenreFantasySet inForgotten RealmsPublished2010PublisherWizards of the CoastPublication placeUnited StatesMedia typePrint (Paperback)Pages345 ((first edition))ISBN978-0786955008OCLC500797204Dewey Decimal813.54LC ClassPS3569.A462345 G38Followed byNeverwinter  Gauntlgrym is a fantasy novel by American writer R. A. Salvatore set…

泰兴县,中国古旧县名。 五代南唐昇元二年(938年)置,治所在延令村(今江苏省泰兴市延令街道),属泰州。北宋乾德二年(964年)移治柴墟镇(今泰兴市高港区口岸街道),元丰四年(1081年)还旧治。南宋属扬州,元、明属扬州路、扬州府,清属通州。县治历有变迁。1992年撤销,改设泰兴市。 查论编江蘇省行政區劃(中華民國政府遷臺前)國別:中華民國 省会:镇江…