As a freshman at Clemson in 2015, Wilkins played in 15 games with one start and had 33 tackles and two sacks.[5][6] As a sophomore in 2016, he was named an All-American by the Football Writers Association of America (FWAA) and was a finalist for the Bronko Nagurski Trophy.[7] Wilkins was part of the Clemson team that defeated top-ranked Alabama in the 2017 College Football Playoff National Championship by a score of 35–31.[8] He also was part of Clemson’s 2018 team that defeated Alabama in the National Championship game led by Trevor Lawrence 44-16.[9] In the Florida State game and South Carolina game of 2018, Wilkins scored a touchdown for the Tigers.
Wilkins was selected by the Miami Dolphins in the first round (13th overall) of the 2019 NFL draft.[13] In a Week 7 loss of 21-31 to the Buffalo Bills, Wilkins was ejected after throwing a punch at Cody Ford on the second play of the game.[14] In Week 9 against the New York Jets, Wilkins recorded his first career sack on Sam Darnold in the 26–18 win.[15] In Week 16 against the Cincinnati Bengals, Wilkins recorded his first career touchdown reception on a pass from Ryan Fitzpatrick in the 38–35 overtime victory.[16]
In Week 8 of the 2020 season against the Los Angeles Rams, Wilkins recorded his first career interception off a pass thrown by Jared Goff during the 28–17 win.[17] Wilkins was placed on the reserve/COVID-19 list by the team on November 12, 2020,[18] and activated on November 25.[19]
In Week 15 of 2021 against the Jets, Wilkins lined up at fullback and recorded his second career touchdown on a flea flicker pass from quarterback Tua Tagovailoa.[20]
The Dolphins picked up the fifth-year option on Wilkins' contract on April 28, 2022.[21]
Wilkins finished 2023 with a career-high nine sacks, establishing himself as a top tier player at his position.[22]
Las Vegas Raiders
On March 14, 2024, the Las Vegas Raiders signed Wilkins to a four-year deal worth $110 million, with $84.75 million guaranteed.[23] Wilkins produced 17 tackles, 2 sacks and 6 QB hits before suffering a foot injury in Week 5 against the Denver Broncos. He is out indefinitely following surgery to repair a Jones fracture.[24]
Bachman, Rachel (April 26, 2019). "The NFL Draft's Most Frugal Player". The Wall Street Journal. Retrieved April 26, 2019. Former Clemson star Christian Wilkins, a projected first-round NFL draft pick, says he'll bring his radical penny-pinching to the pros