Scott made an immediate impact as a true freshman at Clemson in 2014.[4][5] In the second game of the season, he had six receptions for 164 yards and two touchdowns.[6] In the Palmetto Bowl against South Carolina, he had 185 receiving yards and two touchdowns on seven receptions. His totals for the season were 76 receptions for 965 yards and eight touchdowns. As a sophomore in 2015, Scott played 15 games with 93 receptions, 901 receiving yards, and six touchdowns. On January 9, 2017, Scott was part of the Clemson team that defeated Alabama in the 2017 College Football Playoff National Championship by a score of 35–31. In the game, he recorded three receptions for six yards.[7] As a junior in 2016, Scott played 15 games with 614 receiving yards and five touchdowns. After the season, Scott decided to forgo his senior year and enter the 2017 NFL draft.[8]
Scott signed with the Los Angeles Chargers as an undrafted free agent following the 2017 NFL draft and was reunited with former Clemson Tigers teammate Mike Williams.[10] He was waived on September 2, 2017, and was signed to the Chargers' practice squad the next day.[11][12] He signed a reserve/future contract with the Chargers on January 2, 2018.[13]
On September 1, 2018, Scott was placed on injured reserve.[14]
On August 31, 2019, Scott was waived by the Chargers and was signed to the practice squad the next day.[15][16] His practice squad contract with the team expired on January 6, 2020.[17]
Indianapolis Colts
On January 10, 2020, Scott signed a reserve/future contract with the Indianapolis Colts.[18] He was waived on September 3, 2020.[19]
Houston Texans
On November 18, 2020, Scott was signed to the Houston Texans' practice squad.[20] His practice squad contract with the team expired after the season on January 11, 2021.[21]