Aromatherapy

Aromatherapy
Aromatherapy
	A stylized diffuser and a bottle of essential oil
Alternative therapy
MeSH	D019341

Aromatherapy is a practice based on the use of aromatic materials, including essential oils and other aroma compounds, with claims for improving psychological well-being.^[1]^[2]^[3] It is used as a complementary therapy or as a form of alternative medicine, and typically is used via inhalation and not by ingestion.^[2]

Fragrances used in aromatherapy are not approved as prescription drugs in the United States.^[3] Although there is insufficient medical evidence that aromatherapy can prevent, treat or cure any disease,^[1]^[2]^[4] aromatherapy is used by some people with diseases, such as cancer, to provide general well-being and relief from pain, nausea or stress.^[1]^[2] People may use blends of essential oils as a topical application, massage, inhalation, or water immersion.^[1]^[2]^[5] Due to the low quality of research evidence, it is uncertain if aromatherapy provides any benefit to people experiencing nausea after surgery.^[6]

Essential oils comprise hundreds to thousands of aromatic constituents, like terpinoids and phenylpropanoids, and to sufficiently research the pharmacological effects of essential oil constituents, each isolated constituent in the selected essential oil would have to be studied.^[2]^[3]

History

The use of essential oils for therapeutic, spiritual, hygienic and ritualistic purposes goes back to ancient civilizations including the Indians, Chinese, Egyptians, Greeks, and Romans who used them in cosmetics, perfumes and drugs. Oils were used for aesthetic pleasure and in the beauty industry. They were a luxury item and a means of payment. It was believed that essential oils increased the shelf life of wine and improved the taste of food.

Oils and the belief that they had healing properties, along with other beliefs of the time, are described by Dioscorides in his De Materia Medica, written in the 1st century A.D.^[7] Distilled cedarwood oil was used by the ancient Egyptians, and the process of distilling essential oils like rose essence was refined by the 11th century Persian scholar Ibn Sina. Hildegard of Bingen used distilled lavender oil for medicinal treatments in the 12th century, and by the 15th century, oils were commonly distilled from various plant sources.^[8]

In the era of modern medicine, the name "aromatherapy" first appeared in print in 1937 in a French book on the subject: Aromathérapie: Les Huiles Essentielles, Hormones Végétales by René-Maurice Gattefossé, a chemist. An English version was published in 1993.^[9]

Jean Valnet, a French surgeon, pioneered the supposed medicinal uses of essential oils, which he used as antiseptics in the treatment of wounded soldiers during World War II.^[10]

Choice and purchase

Aromatherapy products, and essential oils in particular, may be regulated differently depending on their intended use.^[3] Products that are marketed with a therapeutic use in the US are regulated by the US Food and Drug Administration (FDA); products with a cosmetic use must meet safety requirements, regardless of their source.^[3] The US Federal Trade Commission (FTC) regulates any aromatherapy advertising claims.^[3]

There are no standards for determining the quality of essential oils in the United States; while the term "therapeutic grade" is in use, it does not have a regulatory meaning.^[3]^[11]

Analysis using gas chromatography and mass spectrometry has been used to identify bioactive compounds in essential oils.^[12] These techniques are able to measure the levels of components to a few parts per billion.^[13] This does not make it possible to determine whether each component is natural or whether a poor oil has been "improved" by the addition of synthetic aromachemicals, but the latter is often signalled by the minor impurities present.

Effectiveness

There is no clinical evidence that aromatherapy can prevent or cure any disease,^[1]^[6]^[14] although it may be useful for managing symptoms.^[2]^[15]

Evidence for the efficacy of aromatherapy in treating medical conditions is poor, with a particular lack of studies employing rigorous methodology.^[1]^[2]^[6] In 2015, the Australian Government's Department of Health published the results of a review of alternative therapies that sought to determine if any were suitable for being covered by health insurance; aromatherapy was one of 17 therapies evaluated for which no clear evidence of effectiveness was found.^[16]

A number of systematic reviews have studied the clinical effectiveness of aromatherapy in respect to pain management in labor,^[17] the treatment of post-operative nausea and vomiting,^[6] managing challenging behaviors in people suffering from dementia,^[18] and symptom relief in cancer.^[19]

According to the National Cancer Institute, no studies of aromatherapy in cancer treatment have been published in a peer-reviewed scientific journal. Results are mixed for other studies. Some showed improved sleep,^[20] anxiety, mood, nausea, and pain,^[15] while others showed no change in symptoms.^[21]

Safety concerns

Aromatherapy carries a number of risks of adverse effects; combined with the lack of evidence of its therapeutic benefit, the practice is of questionable worth.^[22]

Many studies have explored the concerns that essential oils are highly concentrated and can irritate the skin when used in undiluted form, often referred to as neat application.^[3]^[23]^[24] Therefore, they are normally diluted with a carrier oil for topical application such as jojoba oil, olive oil, sweet almond oil or coconut oil. Phototoxic reactions may occur with many cold-pressed citrus peel oils such as lemon or lime.^[25]

Many essential oils have chemical components that are sensitisers (meaning that they will, after a number of uses, cause reactions on the skin and more so in the rest of the body).^[3] All cosmetic products and ingredients must meet the same safety requirement, regardless of their source. Chemical composition of essential oils could be affected by herbicides if the original plants are cultivated versus wild-harvested.^[26]^[27] Some oils can be toxic to some domestic animals, with cats being particularly prone.^[28]

Most oils can be toxic to humans as well.^[29] A report on three different cases documented gynecomastia in prepubertal boys who were exposed to topical lavender and tea tree oils.^[30] The Aromatherapy Trade Council of the UK issued a rebuttal.^[31]

Another article published by a different research group also documented three cases of gynecomastia in prepubertal boys who were exposed to topical lavender oil.^[32] Persistent exposure to lavender products may be associated with premature breast development in girls and "that chemicals in lavender oil and tea tree oil are potential endocrine disruptors with varying effects on receptors for two hormones – estrogen and androgen".^[33]

Essential oils can be toxic when ingested or absorbed internally. Doses as low as 2 ml have been reported to cause clinically significant symptoms and severe poisoning can occur after ingestion of as little as 4 ml.^[34] A few reported cases of toxic reactions like liver damage and seizures have occurred after ingestion of sage, hyssop, thuja and cedar oils.^[35] Accidental ingestion may happen when oils are not kept out of reach of children. As with any bioactive substance, an essential oil that may be safe for the general public could still pose hazards for pregnant and lactating women.^[36]

Oils both ingested and applied to the skin can potentially have negative interactions with conventional medicine. For example, the topical use of methyl salicylate–heavy oils like wintergreen may cause bleeding in users taking the anticoagulant warfarin.

In late 2021, an aromatherapy spray was recalled after it was found to be contaminated with Burkholderia pseudomallei, the bacteria that causes melioidosis, which led to four cases of the disease and two deaths.^[37]

References

^ ^a ^b ^c ^d ^e ^f Farrar AJ, Farrar FC (December 2020). "Clinical Aromatherapy". The Nursing Clinics of North America. 55 (4): 489–504. doi:10.1016/j.cnur.2020.06.015. PMC 7520654. PMID 33131627.
^ ^a ^b ^c ^d ^e ^f ^g ^h Editorial Board, PDQ Integrative, Alternative, and Complementary Therapies (13 January 2023). "Aromatherapy With Essential Oils". Bethesda (MD): National Cancer Institute, US National Institutes of Health. PMID 26389313. Retrieved 21 April 2024.{{cite web}}: CS1 maint: multiple names: authors list (link)
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Aromatherapy". US Food and Drug Administration. 28 September 2023. Retrieved 21 April 2024.
^ Lee, Myeong Soo; Choi, Jiae; Posadzki, Paul; Ernst, Edzard (March 2012). "Aromatherapy for health care: An overview of systematic reviews". Maturitas. 71 (3): 257–260. doi:10.1016/j.maturitas.2011.12.018. PMID 22285469.
^ "Home remedies: What are the benefits of aromatherapy?". Mayo Clinic. 8 May 2019. Retrieved 29 July 2023.
^ ^a ^b ^c ^d Hines S, Steels E, Chang A, Gibbons K (March 2018). "Aromatherapy for treatment of postoperative nausea and vomiting". Cochrane Database of Systematic Reviews. 2018 (3): CD007598. doi:10.1002/14651858.CD007598.pub3. PMC 6494172. PMID 29523018.
^ Dioscorides, Pedanius; Goodyer, John (trans.) (1959). Gunther, R.T. (ed.). The Greek Herbal of Dioscorides. New York: Hafner Publishing. p. 34. OCLC 3570794.
^ Scanlan, Nancy (2011). Complementary Medicine for Veterinary Technicians and Nurses. Wiley. p. 204. ISBN 978-0470958896.
^ Gattefossé, R.-M.; Tisserand, R. (1993). Gattefossé's aromatherapy. Saffron Walden: C.W. Daniel. ISBN 0-85207-236-8.^{[page needed]}
^ Valnet, J.; Tisserand, R. (1990). The practice of aromatherapy: A classic compendium of plant medicines & their healing properties. Rochester, VT: Healing Arts Press. ISBN 0-89281-398-9.^{[page needed]}
^ "The Quality of Essential Oils". New York Institute of Aromatic Studies. 1 December 2013. Retrieved 16 March 2020.
^ Song, Shen; Yao, Wei-Feng; Cui, Xiao-bin; Liu, Xiao; Qiu, Rong-Li (2018). "Spectrum-effect relationship analysis by binary chromatographic fingerprint to identify components responsible for the antibacterial activity of the essential oil from Curcumae wenyujin". International Journal of Food Properties. 21 (1). Informa UK Limited: 546–556. doi:10.1080/10942912.2018.1453836. ISSN 1094-2912.
^ Adams, Robert P. (2007). Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry.
^ Barrett, S. "Aromatherapy: Making Dollars out of Scents". Science & Pseudoscience Review in Mental Health. Scientific Review of Mental Health Practice. Retrieved 21 February 2013.
^ ^a ^b Lakhan SE, Sheafer H, Tepper D (2016). "The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis". Pain Research and Treatment. 2016: 13. doi:10.1155/2016/8158693. PMC 5192342. PMID 28070420.
^
Baggoley C (2015). "Review of the Australian Government Rebate on Natural Therapies for Private Health Insurance" (PDF). Australian Government – Department of Health. Archived from the original (PDF) on 26 June 2016. Retrieved 12 December 2015.
- Lay summary in: Gavura, S. (19 November 2015). "Australian review finds no benefit to 17 natural therapies". Science-Based Medicine.
^ Smith CA, Collins CT, Crowther CA (2011). "Aromatherapy for pain management in labour". Cochrane Database Syst Rev (7): CD009215. doi:10.1002/14651858.CD009215. PMID 21735438.
^ Ball, Emily L.; Owen-Booth, Bethan; Gray, Amy; Shenkin, Susan D.; Hewitt, Jonathan; McCleery, Jenny (19 August 2020). "Aromatherapy for dementia". The Cochrane Database of Systematic Reviews. 2020 (8): CD003150. doi:10.1002/14651858.CD003150.pub3. ISSN 1469-493X. PMC 7437395. PMID 32813272.
^ Shin ES, Seo KH, Lee SH, Jang JE, Jung YM, Kim MJ, Yeon JY (2016). "Massage with or without aromatherapy for symptom relief in people with cancer". Cochrane Database Syst Rev. 2016 (6): CD009873. doi:10.1002/14651858.CD009873.pub3. PMC 10406396. PMID 27258432.
^ Her, Jihoo; Cho, Mi-Kyoung (2021). "Effect of aromatherapy on sleep quality of adults and elderly people: A systematic literature review and meta-analysis". Complementary Therapies in Medicine. 60. Elsevier BV: 102739. doi:10.1016/j.ctim.2021.102739. ISSN 0965-2299. PMID 34166869.
^ PDQ (9 March 2007). "Aromatherapy With Essential Oils". National Cancer Institute.
^ Posadzki P, Alotaibi A, Ernst E (2012). "Adverse effects of aromatherapy: a systematic review of case reports and case series". Int J Risk Saf Med. 24 (3): 147–161. doi:10.3233/JRS-2012-0568. PMID 22936057.
^ Manion, Widder, Chelsea, Rebecca (May 2017). "Essentials of essential oils". American Journal of Health-System Pharmacy. 74 (9): e153–e162. doi:10.2146/ajhp151043. PMID 28438819.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Grassman, J; Elstner, E F (1973). "Essential Oils". In Caballero, Benjamin; Trugo, Luiz C; Finglas, Paul M (eds.). Encyclopedia of Food Sciences and Nutrition (2nd ed.). Academic Press. ISBN 0-12-227055-X.^{[page needed]}
^ Cather, JC; MacKnet, MR; Menter, MA (2000). "Hyperpigmented macules and streaks". Proceedings. 13 (4). Baylor University Medical Center: 405–406. doi:10.1080/08998280.2000.11927714. PMC 1312240. PMID 16389350.
^ Edwards, J; Bienvenu, FE (1999). "Investigations into the use of flame and the herbicide, paraquat, to control peppermint rust in north-east Victoria, Australia". Australasian Plant Pathology. 28 (3): 212. doi:10.1071/AP99036. S2CID 36366606.
^ Adamovic, DS. "Variability of herbicide efficiency and their effect upon yield and quality of peppermint (Mentha X Piperital L.)". Retrieved 6 June 2009.
^ Bischoff, K; Guale, F (1998). "Australian Tea Tree (Melaleuca Alternifolia) Oil Poisoning in Three Purebred Cats". Journal of Veterinary Diagnostic Investigation. 10 (2): 208–210. doi:10.1177/104063879801000223. PMID 9576358.
^ American College of Healthcare Sciences (20 April 2017). "Essential Oil". American College of Healthcare Sciences. Accredited Online Holistic Health College. Retrieved 13 April 2019.
^ Henley DV, Lipson N, Korach KS, Bloch CA (2007). "Prepubertal gynecomastia linked to lavender and tea tree oils". N. Engl. J. Med. 356 (5): 479–485. doi:10.1056/NEJMoa064725. PMID 17267908.
^ "Lavender & Tea Tree Oil Rebuttle (sic)". Archived from the original on 13 March 2012. Retrieved 3 October 2010.
^ Diaz A, Luque L, Badar Z, Kornic S, Danon M (2016). "Prepubertal gynecomastia and chronic lavender exposure: report of three cases". J. Pediatr. Endocrinol. Metab. 29 (1): 103–107. doi:10.1515/jpem-2015-0248. PMID 26353172. S2CID 19454282.
^ Weaver, Janelle (2019). "Lavender oil linked to early breast growth in girls". National Institute of Environmental Health Sciences (NIEHS). Archived from the original on 7 April 2022. Retrieved 7 April 2022. Persistent exposure to lavender products is associated with premature breast development in girls, according to new research by NIEHS scientists. The findings also reveal that chemicals in lavender oil and tea tree oil are potential endocrine disruptors with varying effects on receptors for two hormones – estrogen and androgen (see sidebar). The study was published Aug. 8 in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism.
^ "Eucalyptus oil". International Programme on Chemical Safety (UPCS).
^ Millet, Y; Jouglard, J; Steinmetz, MD; Tognetti, P; Joanny, P; Arditti, J (1981). "Toxicity of Some Essential Plant Oils. Clinical and Experimental Study". Clinical Toxicology. 18 (12): 1485–1498. doi:10.3109/15563658108990357. PMID 7333081.
^ Dw, Sibbritt; Cj, Catling; J, Adams; Aj, Shaw; Cs, Homer (March 2014). "The Self-Prescribed Use of Aromatherapy Oils by Pregnant Women". Women and Birth. 27 (1): 41–45. doi:10.1016/j.wombi.2013.09.005. hdl:10453/43623. PMID 24670414.
^ "Aromatherapy spray recalled in U.S. following rare tropical disease deaths". CBC News.

[farrar-1] ^ ^a ^b ^c ^d ^e ^f Farrar AJ, Farrar FC (December 2020). "Clinical Aromatherapy". The Nursing Clinics of North America. 55 (4): 489–504. doi:10.1016/j.cnur.2020.06.015. PMC 7520654. PMID 33131627.

[pdq-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h Editorial Board, PDQ Integrative, Alternative, and Complementary Therapies (13 January 2023). "Aromatherapy With Essential Oils". Bethesda (MD): National Cancer Institute, US National Institutes of Health. PMID 26389313. Retrieved 21 April 2024.{{cite web}}: CS1 maint: multiple names: authors list (link)

[fda-3] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Aromatherapy". US Food and Drug Administration. 28 September 2023. Retrieved 21 April 2024.

[4] Lee, Myeong Soo; Choi, Jiae; Posadzki, Paul; Ernst, Edzard (March 2012). "Aromatherapy for health care: An overview of systematic reviews". Maturitas. 71 (3): 257–260. doi:10.1016/j.maturitas.2011.12.018. PMID 22285469.

[mayo-5] "Home remedies: What are the benefits of aromatherapy?". Mayo Clinic. 8 May 2019. Retrieved 29 July 2023.

[Hines2018-6] Hines S, Steels E, Chang A, Gibbons K (March 2018). "Aromatherapy for treatment of postoperative nausea and vomiting". Cochrane Database of Systematic Reviews. 2018 (3): CD007598. doi:10.1002/14651858.CD007598.pub3. PMC 6494172. PMID 29523018.

[7] Dioscorides, Pedanius; Goodyer, John (trans.) (1959). Gunther, R.T. (ed.). The Greek Herbal of Dioscorides. New York: Hafner Publishing. p. 34. OCLC 3570794.

[8] Scanlan, Nancy (2011). Complementary Medicine for Veterinary Technicians and Nurses. Wiley. p. 204. ISBN 978-0470958896.

[9] Gattefossé, R.-M.; Tisserand, R. (1993). Gattefossé's aromatherapy. Saffron Walden: C.W. Daniel. ISBN 0-85207-236-8.^{[page needed]}

[10] Valnet, J.; Tisserand, R. (1990). The practice of aromatherapy: A classic compendium of plant medicines & their healing properties. Rochester, VT: Healing Arts Press. ISBN 0-89281-398-9.^{[page needed]}

[11] "The Quality of Essential Oils". New York Institute of Aromatic Studies. 1 December 2013. Retrieved 16 March 2020.

[12] Song, Shen; Yao, Wei-Feng; Cui, Xiao-bin; Liu, Xiao; Qiu, Rong-Li (2018). "Spectrum-effect relationship analysis by binary chromatographic fingerprint to identify components responsible for the antibacterial activity of the essential oil from Curcumae wenyujin". International Journal of Food Properties. 21 (1). Informa UK Limited: 546–556. doi:10.1080/10942912.2018.1453836. ISSN 1094-2912.

[13] Adams, Robert P. (2007). Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry.

[Barrett-14] Barrett, S. "Aromatherapy: Making Dollars out of Scents". Science & Pseudoscience Review in Mental Health. Scientific Review of Mental Health Practice. Retrieved 21 February 2013.

[:0-15] Lakhan SE, Sheafer H, Tepper D (2016). "The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis". Pain Research and Treatment. 2016: 13. doi:10.1155/2016/8158693. PMC 5192342. PMID 28070420.

[aus17-16] Baggoley C (2015). "Review of the Australian Government Rebate on Natural Therapies for Private Health Insurance" (PDF). Australian Government – Department of Health. Archived from the original (PDF) on 26 June 2016. Retrieved 12 December 2015.
Lay summary in: Gavura, S. (19 November 2015). "Australian review finds no benefit to 17 natural therapies". Science-Based Medicine.

[17] Lay summary in: Gavura, S. (19 November 2015). "Australian review finds no benefit to 17 natural therapies". Science-Based Medicine.

[17] Smith CA, Collins CT, Crowther CA (2011). "Aromatherapy for pain management in labour". Cochrane Database Syst Rev (7): CD009215. doi:10.1002/14651858.CD009215. PMID 21735438.

[18] Ball, Emily L.; Owen-Booth, Bethan; Gray, Amy; Shenkin, Susan D.; Hewitt, Jonathan; McCleery, Jenny (19 August 2020). "Aromatherapy for dementia". The Cochrane Database of Systematic Reviews. 2020 (8): CD003150. doi:10.1002/14651858.CD003150.pub3. ISSN 1469-493X. PMC 7437395. PMID 32813272.

[19] Shin ES, Seo KH, Lee SH, Jang JE, Jung YM, Kim MJ, Yeon JY (2016). "Massage with or without aromatherapy for symptom relief in people with cancer". Cochrane Database Syst Rev. 2016 (6): CD009873. doi:10.1002/14651858.CD009873.pub3. PMC 10406396. PMID 27258432.

[20] Her, Jihoo; Cho, Mi-Kyoung (2021). "Effect of aromatherapy on sleep quality of adults and elderly people: A systematic literature review and meta-analysis". Complementary Therapies in Medicine. 60. Elsevier BV: 102739. doi:10.1016/j.ctim.2021.102739. ISSN 0965-2299. PMID 34166869.

[Aromatherapy_With_Essential_Oils-21] PDQ (9 March 2007). "Aromatherapy With Essential Oils". National Cancer Institute.

[22] Posadzki P, Alotaibi A, Ernst E (2012). "Adverse effects of aromatherapy: a systematic review of case reports and case series". Int J Risk Saf Med. 24 (3): 147–161. doi:10.3233/JRS-2012-0568. PMID 22936057.

[23] Manion, Widder, Chelsea, Rebecca (May 2017). "Essentials of essential oils". American Journal of Health-System Pharmacy. 74 (9): e153–e162. doi:10.2146/ajhp151043. PMID 28438819.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[24] Grassman, J; Elstner, E F (1973). "Essential Oils". In Caballero, Benjamin; Trugo, Luiz C; Finglas, Paul M (eds.). Encyclopedia of Food Sciences and Nutrition (2nd ed.). Academic Press. ISBN 0-12-227055-X.^{[page needed]}

[25] Cather, JC; MacKnet, MR; Menter, MA (2000). "Hyperpigmented macules and streaks". Proceedings. 13 (4). Baylor University Medical Center: 405–406. doi:10.1080/08998280.2000.11927714. PMC 1312240. PMID 16389350.

[iufh-26] Edwards, J; Bienvenu, FE (1999). "Investigations into the use of flame and the herbicide, paraquat, to control peppermint rust in north-east Victoria, Australia". Australasian Plant Pathology. 28 (3): 212. doi:10.1071/AP99036. S2CID 36366606.

[vhet-27] Adamovic, DS. "Variability of herbicide efficiency and their effect upon yield and quality of peppermint (Mentha X Piperital L.)". Retrieved 6 June 2009.

[28] Bischoff, K; Guale, F (1998). "Australian Tea Tree (Melaleuca Alternifolia) Oil Poisoning in Three Purebred Cats". Journal of Veterinary Diagnostic Investigation. 10 (2): 208–210. doi:10.1177/104063879801000223. PMID 9576358.

[29] American College of Healthcare Sciences (20 April 2017). "Essential Oil". American College of Healthcare Sciences. Accredited Online Holistic Health College. Retrieved 13 April 2019.

[30] Henley DV, Lipson N, Korach KS, Bloch CA (2007). "Prepubertal gynecomastia linked to lavender and tea tree oils". N. Engl. J. Med. 356 (5): 479–485. doi:10.1056/NEJMoa064725. PMID 17267908.

[31] "Lavender & Tea Tree Oil Rebuttle (sic)". Archived from the original on 13 March 2012. Retrieved 3 October 2010.

[32] Diaz A, Luque L, Badar Z, Kornic S, Danon M (2016). "Prepubertal gynecomastia and chronic lavender exposure: report of three cases". J. Pediatr. Endocrinol. Metab. 29 (1): 103–107. doi:10.1515/jpem-2015-0248. PMID 26353172. S2CID 19454282.

[33] Weaver, Janelle (2019). "Lavender oil linked to early breast growth in girls". National Institute of Environmental Health Sciences (NIEHS). Archived from the original on 7 April 2022. Retrieved 7 April 2022. Persistent exposure to lavender products is associated with premature breast development in girls, according to new research by NIEHS scientists. The findings also reveal that chemicals in lavender oil and tea tree oil are potential endocrine disruptors with varying effects on receptors for two hormones – estrogen and androgen (see sidebar). The study was published Aug. 8 in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism.

[34] "Eucalyptus oil". International Programme on Chemical Safety (UPCS).

[35] Millet, Y; Jouglard, J; Steinmetz, MD; Tognetti, P; Joanny, P; Arditti, J (1981). "Toxicity of Some Essential Plant Oils. Clinical and Experimental Study". Clinical Toxicology. 18 (12): 1485–1498. doi:10.3109/15563658108990357. PMID 7333081.

[36] Dw, Sibbritt; Cj, Catling; J, Adams; Aj, Shaw; Cs, Homer (March 2014). "The Self-Prescribed Use of Aromatherapy Oils by Pregnant Women". Women and Birth. 27 (1): 41–45. doi:10.1016/j.wombi.2013.09.005. hdl:10453/43623. PMID 24670414.

[RecalledSpray-37] "Aromatherapy spray recalled in U.S. following rare tropical disease deaths". CBC News.

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Aromatherapy

History

Choice and purchase

Effectiveness

Safety concerns

See also

References

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