ATP1A4

ATP1A4
Identifiers
Aliases	ATP1A4, ATP1A1, ATP1AL2, ATPase Na+/K+ transporting subunit alpha 4
External IDs	OMIM: 607321; MGI: 1351335; HomoloGene: 113769; GeneCards: ATP1A4; OMA:ATP1A4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,186,980 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,085,981 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; testicle; ; sperm; ; seminal vesicula; ; gastrocnemius muscle; ; urinary bladder; ; muscle of thigh; ; gonad; ; lymph node;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; embryo; ; zygote; ; muscle of thigh; ; skeletal muscle tissue; ; subcutaneous adipose tissue; ; white adipose tissue; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; P-type sodium:potassium-exchanging transporter activity; metal ion binding; hydrolase activity; ATP binding; P-type potassium transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; sodium:potassium-exchanging ATPase complex;
Biological process	flagellated sperm motility; establishment or maintenance of transmembrane electrochemical gradient; sodium ion transport; regulation of membrane potential; ion transport; potassium ion transport; regulation of cellular pH; spermatogenesis; fertilization; cellular sodium ion homeostasis; cellular potassium ion homeostasis; sodium ion export across plasma membrane; potassium ion import across plasma membrane; ion transmembrane transport; regulation of cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	480
	27222
	ENSG00000132681
	ENSMUSG00000007107
	Q13733
	Q9WV27
	NM_001001734; NM_144699
	NM_013734
	NP_001001734; NP_653300
	NP_038762
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.^[5]^[6]^[7]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132681 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007107 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC (May 1991). "A detailed multipoint gene map of chromosome 1q". Genomics. 8 (1): 13–21. doi:10.1016/0888-7543(90)90220-O. PMID 1981991.
^ Shull MM, Lingrel JB (Jul 1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc Natl Acad Sci U S A. 84 (12): 4039–43. Bibcode:1987PNAS...84.4039S. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
^ ^a ^b "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide".

External links

Human ATP1A1 genome location and ATP1A1 gene details page in the UCSC Genome Browser.
Human ATP1A4 genome location and ATP1A4 gene details page in the UCSC Genome Browser.