Sindrom Gilbert

Sindrom Gilbert (bahasa Inggris: Gilbert's syndrome, Gilbert-Meulengracht syndrome, GS) merupakan sindrom yang disebabkan oleh defisiensi enzim UGT pada lintasan glusuronik senyawa endogenus, yaitu bilirubin.[1] Penderita GS lebih rentan terhadap efek toksin yang ditimbulkan oleh analgesik seperti asetaminofen. Penimbunan bilirubin yang terjadi pada GS menimbulkan simtoma penyakit kuning.

Rujukan

  1. ^ (Inggris) "Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome". Faculty of Pharmacy, University of Toronto; de Morais SM, Uetrecht JP, Wells PG. Diakses tanggal 2011-05-18. 


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