Coach Diego Vásquez renewed his contract for one year and lead the team for his 16th consecutive tournament.[3][4] Due to poor results in both domestic and international fronts, he was sacked during the Clausura tournament. He broke a league record of 350 consecutive games as manager. He was temporarily recplaced by interim coach and former star César Obando and subsequently by Argentinian manager Hernán Medina, who managed to win the Clausura title.[5]
Kits
The 2021–22 home, away and third kits were published on 15 July.
This is a list of players that were playing for Motagua during the 2021–22 season and were called to represent Honduras at different international competitions.
Note: Fans were allowed to access the stadium again since March 2020. Midfielder Juan Gómez scored his first goal for F.C. Motagua. Jason Sánchez and Yostin Obando made their professional debuts with the club. Obando is the son of former star César Obando.
Note: A late goal on injury time, prevented F.C. Motagua to start the Clausura tournament with points. Forwards Ángel Tejeda and Franco Olego made their debuts for the club wearing jerseys 11 and 9 respectively.
Note: This was manager's Diego Vásquez last match leading the team. Vásquez broke a club's and league's record of 8 plus years and 350 consecutive games as coach.
Note: F.C. Motagua finished the regular season in 4th place. This was the fifth time in Motagua's history winning a match with a margin of six goals or more.
Note: This is the second time in league history that these two clubs faced in this phase. Defender Raúl Santos scored his first league goal for F.C. Motagua.
Note: With a 3–0 score on aggregate, F.C. Motagua advanced to their 14th semifinal in a row. Midfielder Héctor Castellanos reached 200 league games with the club.
Note: This was the first ever F.C. Motagua's encounter against Forge FC, the first one against a Canadian side in this competition and the first one against a Canadian rival in CONCACAF's competitions since 2010.
Note: F.C. Motagua suffered their biggest defeat in international competition in their history. After the elimination, the club's Board of Directors decided to separate manager Diego Vásquez after a record 8+ years as DT. Vásquez would be managing his last game in their next league match.