The 2010 Kilkenny Senior Hurling Championship was the 116th staging of the Kilkenny Senior Hurling Championship since its establishment by the Kilkenny County Board in 1887. The championship began on 18 September 2010 and ended on 24 October 2010.
Ballyhale Shamrocks were the defending champions for the past four years, however their bid for five in a row was ended in the semi-final by O’Loughlin Gaels, who went on to beat Carrickshock 0–17 to 1–11 in the final.[1]
St. Lachtain's were relegated from the championship following 1–11 to 1–14 defeat to Fenians.