Anne Spang erforscht die Grundlagen des intrazellulären Transportes. Internationales Ansehen erlangte Spang durch ihre Entdeckung, dass es einen Reifungsprozess vom frühen zum späten Endosom gibt[2]. Im Fadenwurm Caenorhabditis elegans identifizierte sie SAND-1 als zentralen Schalter, der die Reifung kontrolliert. Darüber hinaus zeigte sie, dass ArfGAP-Proteine wichtig für die Aufnahme von Fracht in Transportvesikel sind und dass COPI-Komponenten eine Rolle im mRNA Transport und mRNA Metabolismus spielen. Ihre Erkenntnisse sind bedeutend für das Verständnis vieler Krankheiten, die auf Defekten in der Lokalisation von Proteinen und mRNA in der Zelle basieren wie Alzheimer, Mukoviszidose, lysosomale Speicherkrankheiten und Krebs.[3]
Kilchert, C. and A. Spang. (2011). Co-translational localization of ABP140 mRNA to the distal pole of yeast cells. EMBO J. 30: 3567-80
Kilchert, C., J. Weidner, C. Prescianotto-Baschong, and A. Spang. (2010). Defects in the secretory pathway and high Ca2+ induce multiple P-bodies. Mol. Biol. Cell. 21: 2624–2638
Poteryaev, D., S. Datta, K. Ackema, M. Zerial, and A. Spang. (2010). Identification of the switch in early-to-late endosome transition. Cell 141:497-508
Poteryaev, D., H. Fares, B. Bowerman, and A. Spang. (2007) Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. EMBO J. 26: 301-312
Schmutz, C., J. Stevens and A. Spang. (2007) Functions of the novel RhoGAPs RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans. Development 134: 3495-3505
Trautwein, M., C. Schindler, R. Gauss, J. Dengjel, E. Hartmann, and A. Spang. (2006) Arf1p, Chs5p, and the ChAPs are required to bud specialized vesicles from the Golgi in Saccharomyces cerevisiae. EMBO J. 25: 943-954
Poteryaev, D., J.M. Squirrell, J.G. White, and A. Spang. (2005). ER dynamics in the early C. elegans embryo require homotypic membrane fusion and the actin cytoskeleton. Mol. Biol. Cell. 16: 2139–2153
Trautwein, M., J. Dengjel, M. Schirle, and A. Spang. (2004). Arf1p provides an unexpected link between vesicular traffic and mRNA transport in Saccharomyces cerevisiae. Mol. Biol. Cell, 15:5021-5037
Lewis, S.M., P.P. Poon, R.A. Singer, G.C. Johnston, and A. Spang. (2004). The Arf-GAP Glo3 is required for the generation of COPI vesicles. Mol. Biol. Cell, 15:4064-4072
Kamena, F. and A. Spang. (2004). Tip20p provides directionality to transport by inhibiting back fusion of COPII vesicles with the endoplasmic reticulum. Science, 304:286-289
Rein, U., U. Andag, R. Duden, H.-D. Schmitt, and A. Spang. (2002). ARF-GAP mediated interaction between the ER-Golgi v-SNAREs and the COPI coat. J. Cell Biol., 157:395-404
Spang, A., and R. Schekman. (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J. Cell Biol., 143:589-599
Spang, A., K. Matsuoka, S. Hamamoto, R. Schekman, and L. Orci. (1998). Coatomer, Arf1p, and nucleotide are required to bud COPI-coated vesicles from large synthetic liposomes. PNAS, 95: 11199-11204.
Spang, A., S. Geissler, K. Grein, and E. Schiebel. (1996). The γ-tubulin-like Tub4p of Saccharomyces cerevisiae is associated with the spindle pole body substructures that organize microtubules and is required for mitotic spindle formation. J. Cell Biol., 134: 429-441.
Spang, A., I. Courtney, U. Fackler, M. Matzner, and E. Schiebel. (1993). The calcium-binding protein cell division cycle 31 of Saccharomyces cerevisiae is a component of the half bridge of the spindle pole body. J. Cell Biol., 123: 405-416.
