Ia menjadi ketua nasional (Supreme Minister) Nation of Islam pada tahun 1975 setelah kematian ayahnya.[5] Sebagai hasil pembelajaran dan pemikirannya, ia berhasil memimpin mayoritas anggota N.O.I. asli beralih ke Islam Sunni yang lebih umum pada tahun 1978.[6] Melalui penggabungan ini, ia memimpin perpindahan massal ke agama Islam terbesar sepanjang sejarah Amerika Serikat.[7] Ia menolak penuhanan Wallace Fard Muhammad sebagaimana yang terjadi sebelumnya, menerima orang kulit putih sebagai sesama pemeluk, mempererat hubungan dengan komunitas Muslim secara umum, dan memperkenalkan Rukun Islam ke teologi organisasinya.[2][8]
Kelompok-kelompok pecahan yang menolak perubahan tersebut dibentuk setelah kematian Elijah Muhammad, khususnya di bawah pimpinan Louis Farrakhan, yang memakai kembali nama Nation of Islam untuk organisasinya.[2][9]
Karya
Buku
The Teachings of W. D. Muhammad, Muhammad's Mosque #2, Chicago, Illinois, 1975
The Lectures of Emam W. D. Muhammad, Muhammad's Mosque #2, Chicago, Illinois, 1976
Book of Muslim Names, The Honorable Elijah Muhammad Mosque #2, Chicago, Illinois, February 1976
The Man and the Woman in Islam, The Honorable Elijah Muhammad Mosque #2, Chicago, Illinois, February 1976
As the Light Shineth from the East, W.D.M. Publications, Chicago, Illinois, 1980
Prayer and Al-Islam, Muhammad Islamic Foundation, Chicago, Illinois, 1982, Library of Congress Card Number: 82-61077
Religion on the Line, W.D.M. Publications, Chicago, Illinois, 1983
Imam W. Deen Muhammad speaks from Harlem, N.Y. Book 1, W. D. M. Publications, 1984
Imam W. Deen Muhammad speaks from Harlem, N.Y.: Challenges That Face Man Today Book 2, 1985
Meeting The Challenge: Halal Foods for Our Everyday Needs, The Honorable Elijah Muhammad Masjid, Chicago, Illinois, 1986
An African American Genesis, M.A.C.A. Publication Fund, Chicago, Illinois, 1986, Library of Congress Card Number: 86-63266
Focus on Al-Islam: Interviews with Imam W. Deen Mohammed, Zakat Publications, Chicago, Illinois, Dec. 1988, Library of Congress Card Number: 89-090728
Mohammed Speaks, W.D.M. Publications, Chicago, Illinois, 1999
Blessed Ramadan - The Fast of Ramadan
Plans for a Better Future: Peace, Inclusion and International Brotherhood
The Schemes Of Satan the Enemy of Man
The Champion We Have In Common: The Dynamic African American Soul Books 1, 2, 3, & 4, The Mosque Cares Publications, August 2005
A Time for Greater Communities Vol. 1-4
Securing our Share of Freedom
Prayer in al-Islam, A Learner's Guide w/Instructional CD, WDM Publications, Chicago, Illinois, 2007
Return to Innocence: Transitioning of the Nation of Islam, The Sense Maker, Chicago, Illinois, 2007
Life The Final Battlefield, W.D.M. Publications, Chicago, Illinois, 2008
Pamflet
A Look At W. Deen Mohammed: Muslim American Spokesman for Human Salvation, A Ministry of W. Deen Mohammed Publication, Chicago, Illinois, 1993
Presentasi video dan audio
Imam W. Deen Mohammed: "Systems of Knowledge", Muslim News Magazine, recorded as a television special by MNM during the 1994 Islamic Convention in Washington, DC. This classroom lecture was delivered in front of more than 200 Imams and scholars at the Renaissance Hotel. "Systems of Knowledge" is a classroom presentation on the essence of Quranic Arabic and its meaning to all mankind. This presentation marked the only time that Imam Mohammed allowed cameras into one of his private Imam classes. RT: 60 minutes. 1994.[butuh rujukan]