SDHB

SDHB
Pengidentifikasi
Alias	SDHB, CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase complex iron sulfur subunit B, MC2DN4
ID eksternal	OMIM: 185470 MGI: 1914930 HomoloGene: 2255 GeneCards: SDHB
Ontologi gen Fungsi molekuler • ubiquinone binding • iron-sulfur cluster binding • metal ion binding • succinate dehydrogenase (ubiquinone) activity • GO:0001948, GO:0016582 Ikatan protein plasma • oxidoreductase activity • electron transfer activity • 2 iron, 2 sulfur cluster binding • 3 iron, 4 sulfur cluster binding • 4 iron, 4 sulfur cluster binding Komponen seluler • membran • Membran sel • nucleoplasm • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) • mitochondrial inner membrane • mitokondria • mitochondrial membranes • respiratory chain complex II Proses biologis • succinate metabolic process • aerobic respiration • Siklus asam sitrat • respiratory electron transport chain • Rantai transpor elektron Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	6390	67680
Ensembl	ENSG00000117118	ENSMUSG00000009863
UniProt	P21912	Q9CQA3
RefSeq (mRNA)	NM_003000	NM_023374 NM_001355515
RefSeq (protein)	NP_002991	NP_075863 NP_001342444
Lokasi (UCSC)	n/a	n/a
Pencarian PubMed	[1]	[2]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

SDHB adalah berkas genetik pada kromosom 1 lokasi 1p36.1-p35 dengan ekspresi genetik berupa protein sub-unit B dari suksinat dehidrogenase. Sub-unit B terdiri dari 3 kluster yang kaya akan sisteina. Mutasi pada gen akan menyebabkan paraganglioma dan feokromositoma, disfungsi mitokondria dan tumorigenesis.[3]

Referensi

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
3. (Inggris) "SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-05.