SDHA

SDHA
Pengidentifikasi
Alias	SDHA, CMD1GG, FP, PGL5, SDH1, SDH2, SDHF, succinate dehydrogenase complex flavoprotein subunit A, MC2DN1, NDAXOA
ID eksternal	OMIM: 600857 MGI: 1914195 HomoloGene: 3073 GeneCards: SDHA
Lokasi gen (Tikus) Kr. Kromosom 13 (tikus)[1] Pita 13|13 C1 Awal 74,470,373 bp[1] Akhir 74,498,399 bp[1]
Ontologi gen Fungsi molekuler • oxidoreductase activity • oxidoreductase activity, acting on the CH-CH group of donors • succinate dehydrogenase activity • GO:0001948, GO:0016582 Ikatan protein plasma • succinate dehydrogenase (ubiquinone) activity • flavin adenine dinucleotide binding • electron transfer activity Komponen seluler • mitochondrial inner membrane • myelin sheath • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) • membran • mitokondria • Nukleolus • plasma membrane succinate dehydrogenase complex Proses biologis • succinate metabolic process • Siklus asam sitrat • perkembangan sistem saraf • Rantai transpor elektron • respiratory electron transport chain • mitochondrial electron transport, succinate to ubiquinone • anaerobic respiration Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	6389	66945
Ensembl	ENSG00000073578	ENSMUSG00000021577
UniProt	P31040	Q8K2B3
RefSeq (mRNA)	NM_001294332 NM_004168 NM_001330758	NM_023281
RefSeq (protein)	NP_001281261 NP_001317687 NP_004159	NP_075770
Lokasi (UCSC)	n/a	Chr 13: 74.47 – 74.5 Mb
Pencarian PubMed	[2]	[3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

SDHA adalah berkas genetik pada kromosom 5 lokasi 5p15 di dalam inti sel, dengan ekspresi genetik berupa flavoprotein yang merupakan sub-unit A dari suksinat hidrogenase. Mutasi pada gen ini berperan dalam defisiensi rantai pernapasan di dalam mitokondria yang dikenal sebagai sindrom Leigh.[4]

Referensi

1. GRCm38: Ensembl release 89: ENSMUSG00000021577 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. (Inggris) "SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-05.