Proakselerin

Proakselerin (bahasa Inggris: proaccelerin, labile factor, plasma accelerator globulin, plasma ac-globulin, accelerator globulin, proprothrombinase, prothrombin conversion accelerator I, Factor V, FV, activated protein C cofactor, factor V Leiden, PCCF, FVL, F5[1]) adalah metabolit berupa protein yang ditemukan dalam plasma darah yang merupakan prekursor dari akselerin.[2] Proakselerin berguna demi mempercepat proses konversi protrombin menjadi trombin.[3]

Proakselerin ditengarai juga bereaksi terhadap protein S.[4][5]

Rujukan

  1. ^ (Inggris) "coagulation factor V". Weizmann Institute of Science. Diakses tanggal 2010-04-28. 
  2. ^ (Inggris) "proaccelerin". Mosby's Dental Dictionary; Elsevier, Inc. Diakses tanggal 2010-04-28. 
  3. ^ (Inggris) "proaccelerin". McGraw-Hill Dictionary of Scientific & Technical Terms. Diakses tanggal 2010-04-28. 
  4. ^ Heeb, M J (1999). "C-terminal residues 621-635 of protein S are essential for binding to factor Va". J. Biol. Chem. UNITED STATES. 274 (51): 36187–92. ISSN 0021-9258. PMID 10593904. 
  5. ^ Heeb, M J (1993). "Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C". J. Biol. Chem. UNITED STATES. 268 (4): 2872–7. ISSN 0021-9258. PMID 8428962. 

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