Enzim pengubah angiotensin

Enzim pengubah angiotensin atau Angiotensin converting enzyme 2 (disingkat ACE2) adalah eksopeptidase yang mengkatalisasi perubahan angiotensin I ke nonapeptide angiotensin (1-9),[1] atau konversi angiotensin II ke angiotensin 1-7.[2][3] ACE2 berdampak langsung pada fungsi jantung,a dan diekspresikan terutama dalam sel endotelium vaskular pada jantung dan ginjal.[4]

Reseptor ACE2 telah terbukti menjadi pintu masuk bagi virus SARS[5] dan 2019-nCoV,[6][7] ke tubuh manusia.

Lihat juga

Referensi

  1. ^ Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S (Sep 2000). "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9". Circulation Research. 87 (5): E1–9. doi:10.1161/01.res.87.5.e1. PMID 10969042. 
  2. ^ Keidar S, Kaplan M, Gamliel-Lazarovich A (Feb 2007). "ACE2 of the heart: From angiotensin I to angiotensin (1-7)". Cardiovascular Research. 73 (3): 463–9. doi:10.1016/j.cardiores.2006.09.006. PMID 17049503. 
  3. ^ Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, Oudit GY (May 2016). "Angiotensin Converting Enzyme 2 Metabolizes and Partially Inactivates Pyrapelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System". Hypertension. 68: 365–77. doi:10.1161/HYPERTENSIONAHA.115.06892. PMID 27217402. 
  4. ^ Boehm M, Nabel EG (Nov 2002). "Angiotensin-converting enzyme 2--a new cardiac regulator". The New England Journal of Medicine. 347 (22): 1795–7. doi:10.1056/NEJMcibr022472. PMID 12456857. 
  5. ^ Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM (Aug 2005). "A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury". Nature Medicine. 11 (8): 875–9. doi:10.1038/nm1267. PMID 16007097. 
  6. ^ Schnirring, Lisa; 2020 (23 January 2020). "WHO holds off on nCoV emergency declaration as cases soar". CIDRAP (dalam bahasa Inggris). Diakses tanggal 24 January 2020. 
  7. ^ Shi, Zheng-Li; Zhou, Peng; Yang, Xing-Lou; Wang, Xian-Guang; Hu, Ben; Zhang, Lei; Zhang, Wei; Si, Hao-Rui; Zhu, Yan; Li, Bei; Huang, Chao-Lin (2020-01-23). "Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin". bioRxiv (dalam bahasa Inggris): 2020.01.22.914952. doi:10.1101/2020.01.22.914952.