ORG-26576

ORG-26576
识别信息
  • (7S)-9-oxa-3,11-diazatricyclo[8.4.0.03,7]tetradeca-1(10),11,13-trien-2-one
CAS号1026791-61-6
PubChem CID
ChemSpider
UNII
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C11H12N2O2
摩尔质量204.23 g·mol−1
3D模型（JSmol（英语：JSmol））
  • C1C[C@H]2COC3=C(C=CC=N3)C(=O)N2C1
  • InChI=1S/C11H12N2O2/c14-11-9-4-1-5-12-10(9)15-7-8-3-2-6-13(8)11/h1,4-5,8H,2-3,6-7H2/t8-/m0/s1
  • Key:FIKUEZUFASUKAH-QMMMGPOBSA-N

ORG-26576是一种有机化合物，分子式C11H12N2O2，最初由RespireRx公司（原称Cortex Pharmaceuticals公司）的科学家研发，后交由欧加农公司继续开发，能有效增强AMPA受体功能，促进脑源性神经营养因子释放[1][2][3]。

参考文献

  1. ^ Jordan GR, McCulloch J, Shahid M, Hill DR, Henry B, Horsburgh K. Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography. Neuropharmacology. August 2005, 49 (2): 254–64. PMID 15993447. S2CID 24805124. doi:10.1016/j.neuropharm.2005.03.011. 
  2. ^ Su XW, Li XY, Banasr M, Koo JW, Shahid M, Henry B, Duman RS. Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus. Psychopharmacology. October 2009, 206 (2): 215–22. PMID 19603152. S2CID 19408716. doi:10.1007/s00213-009-1598-0. 
  3. ^ Hamlyn E, Brand L, Shahid M, Harvey BH. The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats. Behavioural Pharmacology. October 2009, 20 (7): 662–7. PMID 19741506. S2CID 27814943. doi:10.1097/FBP.0b013e328331ba1b. 

外部链接