JWH大麻素列表

克莱门森大学的约翰·威廉·霍夫曼（John William Huffman）研究小组合成了450多种大麻素[1][2]。其中一些是[3][4]：

001—100

大麻素及其Ki值[a]
名称 类别 分子式 Ki/nM (CB1) Ki/nM (CB2) 选择性 结构 CAS编号
JWH-004 萘甲酰基吲哚 C26H27NO 48 ± 13 4 ± 1.5 CB2 (12x) 155471-11-7
JWH-007[5] 萘甲酰基吲哚 C25H25NO 9.5 ± 4.5 2.9 ± 2.6 CB2 (3.3x) 155471-10-6
JWH-009 萘甲酰基吲哚 C27H29NO >10000 141 ± 14 CB2 (>70x) 155471-12-8
JWH-011 萘甲酰基吲哚 C27H29NO 155471-13-9
JWH-015[5] 萘甲酰基吲哚 C23H21NO 164 ± 22 13.8 ± 4.6 CB2 (12x) 155471-08-2
JWH-016 萘甲酰基吲哚 C24H23NO 22 ± 1.5 4.3 ± 1.6 CB2 (5.1x) 155471-09-3
JWH-018[5] 萘甲酰基吲哚 C24H23NO 9 ± 5 2.9 ± 2.6 CB2 (3.1x) 209414-07-3
JWH-019 萘甲酰基吲哚 C25H25NO 9.8 ± 2 5.55 ± 2 CB2 (1.77x) 209414-08-4
JWH-020 萘甲酰基吲哚 C26H27NO 128 ± 17 205 ± 20 CB1 (1.6x) 209414-09-5
JWH-030 萘甲酰基吡咯 C20H21NO 87 ± 3 320 ± 127 CB1 (3.7x) 162934-73-8
JWH-031 萘甲酰基吡咯 C21H23NO 399 ± 109 162934-74-9
JWH-032 萘甲酰基吡咯 C18H17NO >10000 >10000 — 162934-71-6
JWH-033 萘甲酰基吡咯 C19H19NO 666 ± 77 162934-72-7
JWH-036 萘甲酰基吡咯 C22H25NO 309 ± 11 162934-75-0
JWH-042[6] 萘甲酰基吲哚 C21H17NO >10000 5050 ± 192 CB2 209414-02-8
JWH-043[6] 萘甲酰基吲哚 C22H19NO 1180 ± 44 964 ± 242 CB2 (1.2x) 209414-03-9
JWH-044 萘甲酰基吡咯 C16H13NO >10000 >10000 — 209414-10-8
JWH-045 萘甲酰基吡咯 C17H15NO >10000 >10000 — 209414-11-9
JWH-046[6] 萘甲酰基吲哚 C24H23NO 343 ± 38 16.3 ± 4.9 CB2 (21x) 316189-64-7
JWH-047[6] 萘甲酰基吲哚 C25H25NO 59 ± 3 3.47 ± 1.80 CB2 (17x) 316189-65-8
JWH-048[6] 萘甲酰基吲哚 C26H27NO 10.7 ± 1.0 0.49 ± 0.13 CB2 (22x) 316189-66-9
JWH-049[6] 萘甲酰基吲哚 C27H29NO 55.1 ± 17.0 32.3 ± 2.4 CB2 (1.7x) 316189-67-0
JWH-050[6] 萘甲酰基吲哚 C28H31NO 342 ± 6 526 ± 133 CB1 (1.5x) 1348257-03-3
JWH-051 二苯并吡喃 C25H38O2 1.20 0.03 CB2 (40x) 181764-31-8
JWH-056[7] 二苯并吡喃 C21H30O >10000 32 ± 9 CB2 60856-72-6
JWH-057[8] 二苯并吡喃 C25H38O 23 ± 7 2.9 ± 1.6 CB2 (8x) 105823-04-9
JWH-065[7] 二苯并吡喃 C23H34O 399 ± 76 10 ± 2 CB2 (40x) 259869-56-2
JWH-070[6] 萘甲酰基吲哚 C20H15NO >10000 >10000 209414-04-0
JWH-071[6] 萘甲酰基吲哚 C21H17NO 1340 ± 123 2940 ± 852 CB1 (2.2x) 209414-05-1
JWH-072 萘甲酰基吲哚 C22H19NO 1050 ± 5.5 170 ± 54 CB2 (6x) 209414-06-2
JWH-073 萘甲酰基吲哚 C23H21NO 8.9 ± 1.8 27 ± 12 CB1 (3x) 208987-48-8
JWH-076[5] 萘甲酰基吲哚 C23H21NO 214 ± 11 106 ± 46 CB2 (2x) 824960-09-0
JWH-077[6] 萘甲酰基吲哚 C21H17NO2 >10000 >10000 210179-35-4
JWH-078[6] 萘甲酰基吲哚 C22H19NO2 817 ± 60 633 ± 116 CB2 (1.3x) 210179-37-6
JWH-079[6] 萘甲酰基吲哚 C23H21NO2 63.0 ± 3.0 32.0 ± 6.0 CB2 (2x) 210179-40-1
JWH-080[6] 萘甲酰基吲哚 C24H23NO2 8.9 ± 1.8 2.21 ± 1.30 CB2 (4x) 210179-44-5
JWH-081[6] 萘甲酰基吲哚 C25H25NO2 1.2 ± 0.03 12.4 ± 2.2 CB1 (10x) 210179-46-7
JWH-082[6] 萘甲酰基吲哚 C26H27NO2 5.3 ± 0.8 6.40 ± 0.94 CB1 (1.2x) 210179-48-9
JWH-083[6] 萘甲酰基吲哚 C27H29NO2 106 ± 12 102 ± 50 — 316189-69-2
JWH-091[9] (Δ8-THCP) 二苯并吡喃 C23H34O2 22.0 ± 3.9 54763-99-4
JWH-093[6] 萘甲酰基吲哚 C27H29NO2 40.7 ± 2.8 59.1 ± 10.5 CB1 (1.45x) 316189-71-6
JWH-094[6] 萘甲酰基吲哚 C24H23NO2 476 ± 67 97.3 ± 2.7 CB2 (4.9x) 316189-70-5
JWH-095[6] 萘甲酰基吲哚 C29H33NO2 140 ± 4.3 312 ± 83 CB1 (2.2x) 316189-73-8
JWH-096[6] 萘甲酰基吲哚 C25H25NO2 33.7 ± 2.9 13.3 ± 5.6 CB2 (2.5x) 316189-72-7
JWH-097[6] 萘甲酰基吲哚 C31H37NO2 455 ± 28 121 ± 15 CB2 (3.8x) 316189-75-0
JWH-098[6] 萘甲酰基吲哚 C26H27NO2 4.5 ± 0.1 1.9 ± 0.3 CB2 (2.4x) 316189-74-9
JWH-099[6] 萘甲酰基吲哚 C27H29NO2 35.3 ± 9.0 17.8 ± 2.9 CB2 (2x) 316189-76-1
JWH-100[6] 萘甲酰基吲哚 C28H31NO2 381 ± 102 155 ± 74 CB2 (2.5x) 316189-77-2

101—200

大麻素及其Ki值
名称 类别 分子式 Ki/nM (CB1) Ki/nM (CB2) 选择性 结构 CAS编号
JWH-102[7] 二苯并吡喃 C24H38O2 7.9 ± 0.9 5.2 ± 2.0 CB2 (1.5x) 259869-52-8
JWH-103[7] 二苯并吡喃 C24H38O2 28 ± 3 23 ± 7 CB2 (1.2x) 259869-53-9
JWH-116[10] 萘甲酰基吲哚 C26H27NO 52 ± 5 619294-64-3
JWH-120[5] 萘甲酰基吲哚 C23H21NO 1054 ± 31 6.1 ± 0.7 CB2 (173x) 824955-98-8
JWH-121（克羅地亞語：JWH-073 (metilni derivat)）[來源請求] 萘甲酰基吲哚 C24H23NO — 1354631-21-2
JWH-122[10] 萘甲酰基吲哚 C25H25NO 0.69 ± 0.05 1.2 ± 1.2 — 619294-47-2
JWH-124 (Δ8-Parahexyl) 二苯并吡喃 C22H32O2 41.0 ± 3.8 20622-30-4
JWH-130 (Δ8-THCB) 二苯并吡喃 C20H28O2 65.0 ± 13 51768-59-3
JWH-133[7] 二苯并吡喃 C22H32O 677 ± 132 3.4 ± 1.0 CB2 (200x) 259869-55-1
JWH-138[11] 二苯并吡喃 C24H36O2 8.5 ± 1.4 431041-39-3
JWH-139[12] 二苯并吡喃 C21H30O 2290 ± 505 14 ± 10 CB2 (164x) 259869-54-0
JWH-142[7] 二苯并吡喃 C26H40O2 529 ± 49 35 ± 14 CB2 (15x) 174627-56-6
JWH-143[7] 二苯并吡喃 C26H40O2 924 ± 104 65 ± 8 CB2 (14x) 174627-50-0
JWH-145[13] 萘甲酰基吡咯 C26H25NO 14 ± 2 6.4 ± 0.4 CB2 (2.2x) 914458-19-8
JWH-146[13] 萘甲酰基吡咯 C28H29NO 21 ± 2 62 ± 5 CB2 (3.0x) 914458-21-2
JWH-147[13] 萘甲酰基吡咯 C27H27NO 11 ± 1 7.1 ± 0.2 CB2 (1.5x) 914458-20-1
JWH-148[5] 萘甲酰基吲哚 C24H23NO 123 ± 8 14.0 ± 1.0 CB2 (8x) 824955-99-9
JWH-149[5] 萘甲酰基吲哚 C26H27NO 5.0 ± 2.1 0.73 ± 0.03 CB2 (6.8x) 548461-82-1
JWH-150[13] 萘甲酰基吡咯 C25H23NO 60 ± 1 15 ± 2 CB2 (4x) 914458-18-7
JWH-151[5] 萘甲酰基吲哚 C24H23NO2 >10000 30 ± 1.1 CB2 (>333x) 824961-23-1
JWH-153[5] 萘甲酰基吲哚 C26H27NO2 250 ± 24 11 ± 0.5 CB2 (23x) 824961-58-2
JWH-156[13] 萘甲酰基吡咯 C24H21NO 404 ± 18 104 ± 18 CB2 (4x) 914458-17-6
JWH-159[5] 萘甲酰基吲哚 C26H27NO2 45 ± 1 10.4 ± 1.4 CB2 (4.3x) 824961-62-8
JWH-160[5] 萘甲酰基吲哚 C24H23NO2 1568 ± 201 441 ± 110 CB2 (3.6x) 824961-60-6
JWH-161 二苯并吡喃 C27H33NO2 19.0 1349418-89-8
JWH-163[5] 萘甲酰基吲哚 C23H21NO2 2358 ± 215 138 ± 12 CB2 (17x) 824961-06-0
JWH-164[5] 萘甲酰基吲哚 C25H25NO2 6.6 ± 0.7 6.9 ± 0.2 — 824961-61-7
JWH-165[5] 萘甲酰基吲哚 C23H21NO2 204 ± 26 71 ± 8 CB2 (2.9x) 824961-59-3
JWH-166[5] 萘甲酰基吲哚 C25H25NO2 44 ± 10 1.9 ± 0.08 CB2 (23x) 824961-41-3
JWH-167 苯乙酰吲哚 C21H23NO 90 ± 17 159 ± 14 CB1 (1.77x) 864445-37-4
JWH-171 碳氢 C25H24 51 619294-62-1
JWH-175[10] 萘甲基吲哚 C24H25N 22 ± 2 619294-35-8
JWH-176[10] 碳氢 C25H24 26 ± 4 619294-62-1
JWH-180[5] 萘甲酰基吲哚 C25H25NO 26 ± 2 9.6 ± 2.0 CB2 (2.7x) 824959-87-7
JWH-181[5] 萘甲酰基吲哚 C28H31NO 1.3 ± 0.1 0.62 ± 0.04 CB2 (2.1x) 824960-03-4
JWH-182[5] 萘甲酰基吲哚 C27H29NO 0.65 ± 0.03 1.1 ± 0.1 CB1 (1.7x) 824960-02-3
JWH-184[10] 萘甲基吲哚 C25H27N 23 ± 6 619294-37-0
JWH-185[10] 萘甲基吲哚 C25H27NO 17 ± 3 619294-39-2
JWH-186[14] 二苯并吡喃 C21H30O2 187 ± 23 5.6 ± 1.7 CB2 (33x) 824430-33-3
JWH-187[14] 二苯并吡喃 C22H32O2 84 ± 16 3.4 ± 0.5 CB2 (25x) 824430-34-4
JWH-188[14] 二苯并吡喃 C20H28O2 270 ± 58 18 ± 2 CB2 (15x) 824430-32-2
JWH-189[5] 萘甲酰基吲哚 C26H27NO 52 ± 2 12 ± 0.8 CB2 (4.3x) 824960-01-2
JWH-190[14] 二苯并吡喃 C23H34O2 8.8 ± 1.4 1.6 ± 0.03 CB2 (5.5x) 824430-35-5
JWH-191[14] 二苯并吡喃 C24H36O2 1.8 ± 0.3 0.52 ± 0.03 CB2 (3.5x) 824430-36-6
JWH-192[10] 萘甲基吲哚 C26H28N2O 41 ± 13 619294-55-2
JWH-193[10] 萘甲酰基吲哚 C26H26N2O2 6 ± 1 133438-58-1
JWH-194[10] 萘甲基吲哚 C26H29N 127 ± 19 619294-43-8
JWH-195[10] 萘甲基吲哚 C25H26N2O 113 ± 28 619294-53-0
JWH-196[10] 萘甲基吲哚 C25H27N 151 ± 18 619294-41-6
JWH-197[10] 萘甲基吲哚 C26H29NO 323 ± 98 {619294-45-0
JWH-198[10] 萘甲酰基吲哚 C26H26N2O3 10 ± 2 166599-76-4
JWH-199[10] 萘甲基吲哚 C26H28N2O2 20 ± 2 619294-57-4
JWH-200[10] 萘甲酰基吲哚 C25H24N2O2 42 ± 5 103610-04-4

201—300

大麻素及其Ki值
名称 类别 分子式 Ki/nM (CB1) Ki/nM (CB2) 选择性 结构 CAS编号
JWH-201[15] 苯乙酰吲哚 C22H25NO2 1064 ± 21 444 ± 14 CB2 (2.4x) 864445-47-6
JWH-202[15] 苯乙酰吲哚 C23H27NO2 1678 ± 63 645 ± 6 CB2 (2.6x) 864445-48-7
JWH-203[15] 苯乙酰吲哚 C21H22ClNO 8.0 ± 0.9 7.0 ± 1.3 — 864445-54-5
JWH-204[15] 苯乙酰吲哚 C22H24ClNO 13 ± 1 25 ± 1 CB1 (1.9x) 864445-55-6
JWH-205[15] 苯乙酰吲哚 C22H25NO 124 ± 23 180 ± 9 CB1 (1.45x) 864445-38-5
JWH-206[15] 苯乙酰吲哚 C21H22ClNO 389 ± 25 498 ± 37 CB1 (1.28x) 864445-58-9
JWH-207[15] 苯乙酰吲哚 C22H24ClNO 1598 ± 134 3723 ± 10 CB1 (2.33x) 864445-59-0
JWH-208[15] 苯乙酰吲哚 C22H25NO 179 ± 7 570 ± 127 CB1 (3.18x) 864445-41-0
JWH-209[15] 苯乙酰吲哚 C23H27NO 746 ± 49 1353 ± 270 CB1 (1.81x) 864445-42-1
JWH-210[5] 萘甲酰基吲哚 C26H27NO 0.46 ± 0.03 0.69 ± 0.01 CB1 (1.5x) 824959-81-1
JWH-211[5] 萘甲酰基吲哚 C25H25NO 70 ± 0.8 12 ± 0.8 CB2 (5.8x) 824959-72-0
JWH-212[5] 萘甲酰基吲哚 C24H23NO 33 ± 0.9 10 ± 1.2 CB2 (3.3x) 824959-71-9
JWH-213[5] 萘甲酰基吲哚 C27H29NO 1.5 ± 0.2 0.42 ± 0.05 CB2 (3.6x) 824959-83-3
JWH-215[14] 二苯并吡喃 C22H32O3 1008 ± 117 85 ± 21 CB2 (12x) 525588-32-3
JWH-216[14] 二苯并吡喃 C21H30O3 1856 ± 148 333 ± 104 CB2 (5.6x) 525588-30-1
JWH-217[14] 二苯并吡喃 C22H32O2 >10000 1404 ± 66 CB2 (>7x) 525588-02-7
JWH-220 碳氢 C26H26 19
JWH-224[14] 二苯并吡喃 C23H34O3 347 ± 34 28 ± 1 CB2 (12.3x) 525588-34-5
JWH-225[14] 二苯并吡喃 C23H34O2 >10000 325 ± 70 CB2 (>31x) 525588-03-8
JWH-226[14] 二苯并吡喃 C24H36O2 4001 ± 282 43 ± 3 CB2 (93x) 525588-04-9
JWH-227[14] 二苯并吡喃 C24H36O3 40 ± 6 4.4 ± 0.3 CB2 (9x) 525588-36-7
JWH-229[16] 二苯并吡喃 C25H38O2 3134 ± 110 18 ± 2 CB2 (174x) 832111-99-6
JWH-230[14] 二苯并吡喃 C25H38O3 15 ± 3 1.4 ± 0.12 CB2 (10.7x) 525588-38-9
JWH-233[14] 二苯并吡喃 C26H40O3 14 ± 3 1.0 ± 0.3 CB2 (14x) 137945-55-2 （(6aR,10aR)）
2309315-66-8 （(6aS,10aS)）
JWH-234[5] 萘甲酰基吲哚 C26H27NO 8.4 ± 1.8 3.8 ± 0.6 CB2 (2.2x) 824960-64-7
JWH-235[5] 萘甲酰基吲哚 C24H23NO 338 ± 34 123 ± 34 CB2 (2.7x) 824960-57-8
JWH-236[5] 萘甲酰基吲哚 C25H25NO 1351 ± 204 240 ± 63 CB2 (5.6x) 824960-63-6
JWH-237[15] 苯乙酰吲哚 C21H22ClNO 38 ± 10 106 ± 2 CB1 (2.8x) 864445-56-7
JWH-239[5] 萘甲酰基吲哚 C26H27NO 342 ± 20 52 ± 6 CB2 (6.6x) 824960-04-5
JWH-240[5] 萘甲酰基吲哚 C28H31NO 14 ± 1 7.2 ± 1.3 CB2 (1.9x) 824960-06-7
JWH-241[5] 萘甲酰基吲哚 C27H29NO 147 ± 20 49 ± 7 CB2 (3.0x) 824960-05-6
JWH-242[5] 萘甲酰基吲哚 C29H33NO 42 ± 9 6.5 ± 0.3 CB2 (6.5x) 824960-07-8
JWH-243[13] 萘甲酰基吡咯 C27H27NO2 285 ± 40 41 ± 3 CB2 (6.95x) 914458-38-1
JWH-244[13] 萘甲酰基吡咯 C27H27NO 130 ± 6 18 ± 1 CB2 (7.22x) 914458-35-8
JWH-245[13] 萘甲酰基吡咯 C26H24ClNO 276 ± 4 25 ± 2 CB2 (11x) 914458-40-5
JWH-246[13] 萘甲酰基吡咯 C26H24ClNO 70 ± 4 16 ± 1 CB2 (4.38x) 914458-32-5
JWH-247[14] 二苯并吡喃 C25H38O2 427 ± 31 99 ± 4 CB2 (4.3x) 873428-67-2
JWH-248[15] 苯乙酰吲哚 C21H22BrNO 1028 ± 39 657 ± 19 CB2 (1.56x) 864445-62-5
JWH-249[15] 苯乙酰吲哚 C21H22BrNO 8.4 ± 1.8 20 ± 2 CB1 (2.38x) 864445-60-3
JWH-250[15] 苯乙酰吲哚 C22H25NO2 11 ± 2 33 ± 2 CB1 (3x) 864445-43-2
JWH-251[15] 苯乙酰吲哚 C22H25NO 29 ± 3 146 ± 36 CB2 (5x) 864445-39-6
JWH-252[15] 苯乙酰吲哚 C23H27NO 23 ± 3 19 ± 1 CB2 (1.2x) 864445-40-9
JWH-253[15] 苯乙酰吲哚 C23H27NO2 62 ± 10 84 ± 12 CB1 (1.35x) 864445-46-5
JWH-254[14] 二苯并吡喃 C23H34O2 4724 ± 509 319 ± 16 CB2 (14.8x) 873428-46-7
JWH-256[14] 二苯并吡喃 C24H36O2 4300 ± 888 97 ± 18 CB2 (44x) 873428-65-0
JWH-258[5] 萘甲酰基吲哚 C26H27NO2 4.6 ± 0.6 10.5 ± 1.3 CB1 (2.3x) 824960-97-6
JWH-259[5] 萘甲酰基吲哚 C24H23NO2 220 ± 29 74 ± 7 CB2 (3.0x) 824960-95-4
JWH-260[5] 萘甲酰基吲哚 C27H29NO2 29 ± 0.4 25 ± 1.9 CB2 (1.2x) 824960-98-7
JWH-261[5] 萘甲酰基吲哚 C25H25NO2 767 ± 105 221 ± 14 CB2 (3.5x) 824960-96-5
JWH-262[5] 萘甲酰基吲哚 C27H29NO 28 ± 3 5.6 ± 0.7 CB2 (5.0x) 824960-71-6
JWH-265[5] 萘甲酰基吲哚 C23H21NO2 3788 ± 323 80 ± 13 CB2 (47x) 824960-73-8
JWH-266[5] 萘甲酰基吲哚 C24H23NO2 >10000 455 ± 55 CB2 (>22x) 824960-74-9
JWH-267[5] 萘甲酰基吲哚 C25H25NO2 381 ± 16 7.2 ± 0.14 CB2 (53x) 824960-76-1
JWH-268[5] 萘甲酰基吲哚 C26H27NO2 1379 ± 193 40 ± 0.6 CB2 (34x) 824960-77-2
JWH-277[14] 二苯并吡喃 C22H34O3 3905 ± 91 589 ± 65 CB2 (6.6x) 883111-60-2
JWH-278[14] 二苯并吡喃 C23H36O3 906 ± 80 69 ± 6 CB2 (13x) 883111-61-3
JWH-292[13] 萘甲酰基吡咯 C27H27NO2 29 ± 1 20 ± 1 CB2 (1.45x) 914458-25-6
JWH-293[13] 萘甲酰基吡咯 C26H24N2O3 100 ± 5 41 ± 4 CB2 (2.44x) 914458-34-7
JWH-298[14] 二苯并吡喃 C22H34O3 812 ± 67 198 ± 23 CB2 (4.1x) 883111-53-3
JWH-299[14] 二苯并吡喃 C23H36O3 415 ± 50 30 ± 2 CB2 (13.8x) 883111-54-4
JWH-300[12] 二苯并吡喃 C22H34O2 118 ± 16 5.3 ± 0.1 CB2 (22x) 883111-58-8

301—400

大麻素及其Ki值
名称 类别 分子式 Ki/nM (CB1) Ki/nM (CB2) 选择性 结构 CAS编号
JWH-301[14] 二苯并吡喃 C22H34O2 295 ± 64 48 ± 4 CB2 (6.1x) 883111-65-7
JWH-302[15] 苯乙酰吲哚 C22H25NO2 17 ± 2 89 ± 15 CB1 (5.26x) 864445-45-4
JWH-303[15] 苯乙酰吲哚 C22H24ClNO 117 ± 10 138 ± 12 CB1 (1.18x) 864445-57-8
JWH-304[15] 苯乙酰吲哚 C22H24BrNO 3363 ± 332 2679 ± 688 CB2 (1.26x) 864445-63-6
JWH-305[15] 苯乙酰吲哚 C22H24BrNO 15 ± 1.8 29 ± 5 CB1 (1.93x) 864445-61-4
JWH-306[15] 苯乙酰吲哚 C23H27NO2 25 ± 1 82 ± 11 CB1 (3.28x) 864445-44-3
JWH-307[13] 萘甲酰基吡咯 C26H24FNO 7.7 ± 1.8 3.3 ± 0.2 CB2 (2.33x) 914458-26-7
JWH-308[13] 萘甲酰基吡咯 C26H24FNO 41 ± 1 33 ± 2 CB2 (1.24x) 914458-42-7
JWH-309[13] 萘甲酰基吡咯 C30H27NO 41 ± 3 49 ± 7 CB1 (1.20x) 914458-42-7
JWH-310[14] 二苯并吡喃 C21H32O2 1059 ± 51 36 ± 3 CB2 (29x) 883111-57-7
JWH-311[15] 苯乙酰吲哚 C21H22FNO 23 ± 2 39 ± 3 CB1 (1.70x) 864445-49-8
JWH-312[15] 苯乙酰吲哚 C21H22FNO 72 ± 7 91 ± 20 CB1 (1.26x) 864445-50-1
JWH-313[15] 苯乙酰吲哚 C21H22FNO 422 ± 19 365 ± 92 CB2 (1.16x) 864445-52-3
JWH-314[15] 苯乙酰吲哚 C22H24FNO 39 ± 2 76 ± 4 CB1 (1.95x) 864382-14-9
JWH-315[15] 苯乙酰吲哚 C22H24FNO 430 ± 24 182 ± 23 CB2 (3.36x) 864445-51-2
JWH-316[15] 苯乙酰吲哚 C22H24FNO 2862 ± 670 781 ± 105 CB2 (3.66x) 864445-53-4
JWH-336[12] 二苯并吡喃 C21H32O2 4589 ± 367 153 ± 15 CB2 (30x) 883111-64-6
JWH-338[14] 二苯并吡喃 C20H28O >10000 111 ± 16 CB2 (>90x) 873428-27-4
JWH-339[14] 二苯并吡喃 C21H30O2 >10000 2317 ± 93 CB2 (>4.3x) 873428-28-5
JWH-340[14] 二苯并吡喃 C25H40O3 135 ± 6 30 ± 1 CB2 (4.5x) 259869-53-9
JWH-341[14] 二苯并吡喃 C25H40O3 100 ± 8 10 ± 0.1 CB2 (10x) 259869-52-8
JWH-346[13] 萘甲酰基吡咯 C27H27NO 67 ± 6 39 ± 2 CB2 (1.72x) 914458-29-0
JWH-347[13] 萘甲酰基吡咯 C30H27NO 333 ± 17 169 ± 17 CB2 (1.97x) 914458-43-8
JWH-348[13] 萘甲酰基吡咯 C27H24F3NO 218 ± 19 53 ± 1 CB2 (4.11x) 914458-41-6
JWH-349[14] 二苯并吡喃 C24H38O3 376 ± 1 38 ± 4 CB2 (9.9x) 883111-67-9
JWH-350[12] 二苯并吡喃 C24H38O3 395 ± 50 12 ± 1 CB2 (33x) 883111-59-9
JWH-351[14] 二苯并吡喃 C22H32O2 >10000 295 ± 3 CB2 (>34x) 873428-30-9
JWH-352[14] 二苯并吡喃 C21H30O >10000 47 ± 2 CB2 (>213x) 873556-64-0
JWH-353[14] 二苯并吡喃 C22H32O 1493 ± 10 31 ± 1 CB2 (48x) 873556-72-0
JWH-354[14] 二苯并吡喃 C23H34O2 1961 ± 21 241 ± 14 CB2 (8.1x) 873428-58-1
JWH-355[14] 二苯并吡喃 C23H34O 2162 ± 220 108 ± 17 CB2 (20x) 873428-49-0
JWH-356[14] 二苯并吡喃 C24H36O2 5837 ± 701 108 ± 17 CB2 (54x) 873428-61-6
JWH-357[14] 二苯并吡喃 C24H36O 647 ± 78 185 ± 4 CB2 (3.5x) 873428-50-3
JWH-358[14] 二苯并吡喃 C25H38O2 1243 ± 266 52 ± 3 CB2 (24x) 873428-63-8
JWH-359 二苯并吡喃 C24H36O2 2918 ± 450 13.0 ± 0.2 CB2 (220x)
JWH-360[14] 二苯并吡喃 C21H30O 2449 ± 606 160 ± 8 CB2 (15x) 873428-44-5
JWH-361[14] 二苯并吡喃 C23H36O2 63 ± 3 2.7 ± 0.1 CB2 (23x) 883111-59-9
JWH-362[14] 二苯并吡喃 C23H36O2 127 ± 8 34 ± 5 CB2 (3.7x) 883111-67-9
JWH-363[13] 萘甲酰基吡咯 C27H24F3NO 245 ± 5 71 ± 1 CB2 (3.45x) 914458-33-6
JWH-364[13] 萘甲酰基吡咯 C28H29NO 34 ± 3 29 ± 1 CB2 (1.17x) 914458-36-9
JWH-365[13] 萘甲酰基吡咯 C28H29NO 17 ± 1 3.4 ± 0.2 CB2 (5.0x) 914458-23-4
JWH-366[13] 萘甲酰基吡咯 C25H24N2O 191 ± 12 24 ± 1 CB2 (7.96x) 914458-44-9
JWH-367[13] 萘甲酰基吡咯 C27H27NO2 53 ± 2 23 ± 1 CB2 (2.30x) 914458-30-3
JWH-368[13] 萘甲酰基吡咯 C26H24FNO2 16 ± 1 9.1 ± 0.7 CB2 (1.76x) 914458-31-4
JWH-369[13] 萘甲酰基吡咯 C26H24ClNO2 7.9 ± 0.4 5.2 ± 0.3 CB2 (1.52x) 914458-27-8
JWH-370[13] 萘甲酰基吡咯 C27H27NO 5.6 ± 0.4 4.0 ± 0.5 CB2 (1.40x) 914458-22-3
JWH-371[13] 萘甲酰基吡咯 C30H33NO 42 ± 1 64 ± 2 CB1 (1.52x) 914458-37-0
JWH-372[13] 萘甲酰基吡咯 C27H24F3NO 77 ± 2 8.2 ± 0.2 CB1 (9.39x) 914458-28-9
JWH-373[13] 萘甲酰基吡咯 C30H33NO 60 ± 3 69 ± 2 CB1 (1.15x) 914458-37-0
JWH-387[17] 萘甲酰基吲哚 C24H22BrNO 1.2 ± 0.1 1.1 ± 0.1 — 1366067-59-5
JWH-398[18] 萘甲酰基吲哚 C24H22ClNO 2.3 ± 0.1 2.8 ± 0.2 CB1 (1.22x) 1292765-18-4

401—

大麻素及其Ki值
名称 类别 分子式 Ki/nM (CB1) Ki/nM (CB2) 选择性 结构 CAS编号
JWH-416[17] 萘甲酰基吲哚 C24H22INO 73 ± 10 3.3 ± 0.1 CB2 (22x) 1366068-19-0
JWH-417[17] 萘甲酰基吲哚 C25H24INO 522 ± 58 13 ± 0.2 CB2 (40x) 1366068-23-6
JWH-422[17] 萘甲酰基吲哚 C23H20INO 501 ± 48 20 ± 0.4 CB2 (25x) 1366067-69-7
JWH-423[17] 萘甲酰基吲哚 C22H18INO 140 ± 10 6.6 ± 0.2 CB2 (21x) 1366067-66-4
JWH-424[17] 萘甲酰基吲哚 C24H22BrNO 21 ± 3.4 5.4 ± 0.2 CB2 (3.9x) 1366068-04-3
JWH-425[17] 萘甲酰基吲哚 C25H24BrNO 54 ± 11 10 ± 0.4 CB2 (5.4x) 1366068-07-6

参见

注释

  1. ^ Ki是化合物对大麻素1型受体（CB1）或大麻素2型受体（CB2）的结合亲和力

参考资料

  1. ^ Manera C, Tuccinardi T, Martinelli A. Indoles and related compounds as cannabinoid ligands. Mini Rev Med Chem. 2008, 8 (4): 370–87. PMID 18473928. doi:10.2174/138955708783955935. 
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  5. ^ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 5.22 5.23 5.24 5.25 5.26 5.27 5.28 5.29 5.30 5.31 5.32 5.33 5.34 5.35 5.36 5.37 5.38 Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. Bioorganic & Medicinal Chemistry. January 2005, 13 (1): 89–112. PMID 15582455. doi:10.1016/j.bmc.2004.09.050. 
  6. ^ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 6.20 6.21 6.22 6.23 Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding. Drug and Alcohol Dependence. August 2000, 60 (2): 133–40. PMID 10940540. doi:10.1016/S0376-8716(99)00152-0. 
  7. ^ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, Martin BR. 3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorganic & Medicinal Chemistry. December 1999, 7 (12): 2905–14. PMID 10658595. doi:10.1016/s0968-0896(99)00219-9. 
  8. ^ Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett RD, Reggio PH. Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. Journal of Medicinal Chemistry. September 1996, 39 (20): 3875–7. PMID 8831752. doi:10.1021/JM960394Y. 
  9. ^ Bow EW, Rimoldi JM. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspect Medicin Chem. 2016 Jun 28;8:17-39. doi:10.4137/PMC.S32171 PMID 27398024
  10. ^ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 10.12 10.13 10.14 Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR. 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor. Bioorganic & Medicinal Chemistry. February 2003, 11 (4): 539–49. PMID 12538019. S2CID 29107765. doi:10.1016/S0968-0896(02)00451-0. 
  11. ^ Martin BR, Jefferson R, Winckler R, Wiley JL, Huffman JW, Crocker PJ, Saha B, Razdan RK. Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists. J Pharmacol Exp Ther. 1999 Sep;290(3):1065-79. PMID 10454479
  12. ^ 12.0 12.1 12.2 12.3 Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological Reviews. June 2002, 54 (2): 161–202. PMID 12037135. S2CID 8259002. doi:10.1124/pr.54.2.161. 
  13. ^ 13.00 13.01 13.02 13.03 13.04 13.05 13.06 13.07 13.08 13.09 13.10 13.11 13.12 13.13 13.14 13.15 13.16 13.17 13.18 13.19 13.20 13.21 13.22 13.23 13.24 13.25 13.26 13.27 Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorganic & Medicinal Chemistry Letters. October 2006, 16 (20): 5432–5. PMID 16889960. doi:10.1016/j.bmcl.2006.07.051. 
  14. ^ 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 14.11 14.12 14.13 14.14 14.15 14.16 14.17 14.18 14.19 14.20 14.21 14.22 14.23 14.24 14.25 14.26 14.27 14.28 14.29 14.30 14.31 14.32 14.33 14.34 14.35 14.36 14.37 14.38 Marriott KS, Huffman JW. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Current Topics in Medicinal Chemistry. 2008, 8 (3): 187–204. PMID 18289088. doi:10.2174/156802608783498014. 
  15. ^ 15.00 15.01 15.02 15.03 15.04 15.05 15.06 15.07 15.08 15.09 15.10 15.11 15.12 15.13 15.14 15.15 15.16 15.17 15.18 15.19 15.20 15.21 15.22 15.23 15.24 15.25 15.26 Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorganic & Medicinal Chemistry Letters. September 2005, 15 (18): 4110–3. PMID 16005223. doi:10.1016/j.bmcl.2005.06.008. 
  16. ^ Huffman JW, Bushell SM, Miller JR, Wiley JL, Martin BR. 1-Methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Delta(8)-tetrahydrocannabinols: new selective ligands for the CB2 receptor. Bioorganic & Medicinal Chemistry. December 2002, 10 (12): 4119–29. PMID 12413866. doi:10.1016/s0968-0896(02)00331-0. 
  17. ^ 17.0 17.1 17.2 17.3 17.4 17.5 17.6 Wiley JL, Smith VJ, Chen J, Martin BR, Huffman JW. Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents. Bioorganic & Medicinal Chemistry. 2012, 20 (6): 2067–2081. PMC 3298571 可免费查阅. PMID 22341572. doi:10.1016/j.bmc.2012.01.038. 
  18. ^ The Cannabinoid Receptors. The Receptors. 2009. ISBN 978-1-58829-712-9. doi:10.1007/978-1-59745-503-9.