zh 4-%E7%BE%9F%E5%9F%BA%E9%9B%8C%E4%BA%8C%E9%86%87

4-羟基雌二醇
	IUPAC名; (8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol
别名	4-OHE2; Estra-1,3,5(10)-triene-3,4,17β-triol; 3,4,17β-Trihydroxyestra-1,3,5(10)-triene
识别
CAS号	5976-61-4
PubChem	5282360
ChemSpider	4445523
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4O)O;
ChEBI	62845
KEGG	C14209
性质
化学式	C18H24O3
摩尔质量	288.38 g·mol−1
熔点	252—253 °C（525—526 K）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

4-羟基雌二醇（英語：4-Hydroxyestradiol，缩写4-OHE2，或称为雌甾-1,3,5(10)-三烯-3,4,17β-三醇，estra-1,3,5(10)-triene-3,4,17β-triol）是一种内源性的天然儿茶酚雌激素和雌酮与雌二醇的次要代謝產物^[2]，带有一定的雌激素活性^[2]^[3]。

参考资料

^ Hecker, Erich; Walk, Elisabeth. The chemistry of the p-quinols. III. o-Quinone diacetates and amino analogs of natural estrogens. Chemische Berichte, 1960. 93: 2928-2937. ISSN: 0009-2940.
^ ^2.0 ^2.1 Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 224, 232, 244–245, 249. ISBN 978-3-642-58616-3.
^ Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. J. Soc. Gynecol. Investig. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6.

外部链接

Metabocard for 4-Hydroxyestradiol - Human Metabolome Database （页面存档备份，存于互联网档案馆）

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[1] Hecker, Erich; Walk, Elisabeth. The chemistry of the p-quinols. III. o-Quinone diacetates and amino analogs of natural estrogens. Chemische Berichte, 1960. 93: 2928-2937. ISSN: 0009-2940.

[OettelSchillinger2012-2] 2.0 ^2.1 Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 224, 232, 244–245, 249. ISBN 978-3-642-58616-3.

[pmid10865186-3] Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. J. Soc. Gynecol. Investig. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6.

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