替利定

替利定
(1S,2R)-tilidine (dextilidine; top),
(1R,2S)-tilidine (bottom)
[skeletal diagram 2D]
(1S,2R)-tilidine (dextilidine; top),
(1R,2S)-tilidine (bottom)
[ball-and-stick diagram 3D]
臨床資料
商品名（英语：Drug nomenclature）Valoron, others
其他名稱Tilidate (BAN UK)
AHFS/Drugs.com国际药品名称
给药途径By mouth, rectal, intramuscular, intravenous
藥物類別（英语：Drug class）Opioid
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度6% (parent compound), 99% (active metabolite)[1]
药物代谢Metabolized by the liver, mostly via the enzymes CYP3A4 and CYP2C19[2]
藥效起始時間（英语：Onset of action）10–15 minutes
生物半衰期3–5 hours[2]
作用時間4–6 hours
排泄途徑Urine (90%)[2]
识别信息
  • Ethyl (1R,2S)-rel-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
CAS号51931-66-9  checkY
DrugBank
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.039.779 編輯維基數據鏈接
化学信息
化学式C17H23NO2
摩尔质量273.38 g·mol−1
3D模型（JSmol（英语：JSmol））
  • O=C(OCC)[C@@]1(CCC=C[C@H]1N(C)C)C2=CC=CC=C2

替利定（英語：Tilidine，商品名：Valoron等）是一种含氮有机化合物，化学式为C17H23NO2，属于類阿片镇痛药，用于中度至重度疼痛[4][5]。

参考文献

  1. ^ Vollmer KO, Thomann P, Hengy H. Pharmacokinetics of tilidine and metabolites in man. Arzneimittel-Forschung. October 1989, 39 (10): 1283–8. PMID 2610722. 
  2. ^ 2.0 2.1 2.2 Tilidin N Sandoz® DP Lösung zum Einnehmen [Tilidin N Sandoz ® DP oral solution] (PDF). Wooden Churches: Sandoz Pharmaceuticals GmbH. December 2012 [18 April 2014]. （原始内容 (PDF)存档于2 May 2014） （德语）. 
  3. ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. （原始内容存档于2023-08-03） （巴西葡萄牙语）. 
  4. ^ Brayfield A (编). Tilidine Hydrochloride. Martindale: The Complete Drug Reference. Pharmaceutical Press. 13 December 2013 [18 April 2014]. 
  5. ^ Tilidine. Drugs.com. [8 February 2020] （英语）.