The aim of this study was to obtain empirical evidence and clarity about the influence of the phenomenon of personality, motivation to career success, either partially or simultaneously based on self-leadership theory. In addition, to determine whether there is differences in personality, motivation to career success between men and women. The unit of analysis is a lecturer in the area of Cirebon region. The total samples are 120 people. The method used is descriptive and verification method. To test the model and hypotheses used regression analysis. The results showed that personality and motivation affects the career success. The Influential of personality and motivation of success is together toward career success. There was no difference in personality, motivation to career success among male and female in the college.