Background: Submission of preliminary true information, accurate and easily understood by the midwife to the acceptor isvery important to avoid mistakes of usage. Mistakes can cause failure of contraception usage. Importance of initialinformation provided, making it as key to the successful use of contraceptive method.Objective: This study aims to determine the relationship characteristics of midwives with knowledge of the contraceptivepill combination in the public health center located in Cirebon district.Methods: This study is correlation study with cross sectional design. The data collected is primary data. The data obtained from surveys using a questionnaire about the characteristics of respondents and knowledge of the combined contraceptive pill. Respondents are the midwives who work in public health centers located in Cirebon district. Data analysis using Chi square test at α = 0.05. Data collected from 212 respondents (n = 212).Results: Most of the midwife of public health centers in Cirebon district still educated in Diploma III as much as 179 midwives (84.4%), mostly aged <40 years as many as 182 midwives (85.8%), and most of them work in public health centers non PONED as many as 187 midwives (88, 2%). There was a significant correlation between the characteristics of midwives with the knowledge of the contraceptive pill combination in terms of educational background and age (p <0.05), while the terms of the workplace there is no significant correlation (p> 0.05).Conclusion: Education and age characteristics associated with midwife knowledge about contraceptive pill combinations. The implications of the results of the study recommended the need for government and professional midwives continue to provide learning opportunities at a better level for midwives to improve the quality of knowledge and health services provided by midwives to communities, the need for better coaching efforts to improve the experience of midwives, especially the necessary efforts guidance from the District Health Department in form of dissemination of knowledge through seminars, discussions, training and practical guidance from experts and experienced midwives. Numbers of midwives who are still working in non PONED public health centers indicate the need of government to increase health care facilities better so that it will provide the opportunity for midwives to provide better quality services in public healthcenters as PONED public health centers with better facilities.Keywords: Education and age, PONED public health centers, knowledge, contraceptive pill combination.