The purpose of this research is to investigate the effect of spiritual leadership model on work engagement through the meaning/calling and membership. This study is a quantitative research using primary data collected through a questionnaire survey. Testing was conducted to 106 employees from the Islamic Hospital in Yogyakarta. The Structural Equation Modeling (SEM) with path analysis was used to test the impact and to determine the model that best describes the relationship of the model. The results show that spiritual leadership with values, attitudes, and behaviors of leaders has a significant positive effect on meaning/calling, and membership of the employees. Further, meaning/ calling facilitates employees to enhance the level of work engagement. However, membership does not have a significant effect on enhancing the level of work engagement.