エンド-α-シアリダーゼ

エンド-α-シアリダーゼ
識別子
EC番号 3.2.1.129
CAS登録番号 91195-87-8
データベース
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB構造 RCSB PDB PDBj PDBe PDBsum
検索
PMC articles
PubMed articles
NCBI proteins
テンプレートを表示

エンド-α-シアリダーゼ（Endo-alpha-sialidase、EC 3.2.1.129）は、系統名をポリシアロシド (2->8)-α-シアロシルヒドロラーゼ (polysialoside (2->8)-alpha-sialosylhydrolase)という酵素である[1][2][3][4][5][6][7]。他に、endo-N-acylneuraminidase, endoneuraminidase, endo-N-acetylneuraminidase, poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase, poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase, endosialidase, endo-N等とも呼ばれる。以下の化学反応を触媒する。

オリゴまたはポリシアル酸の(2->8)-α-シアロシル結合をエンド型で加水分解する。

出典

  1. ^ “Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid”. The Journal of Biological Chemistry 260 (2): 1265–70. (January 1985). PMID 3968060. 
  2. ^ “Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-alpha-2,8-sialosyl carbohydrate units”. The Journal of Biological Chemistry 262 (8): 3553–61. (March 1987). PMID 3546309. 
  3. ^ “Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies”. The Journal of Biological Chemistry 263 (34): 18269–76. (December 1988). PMID 3142874. 
  4. ^ “Endo-N-acetylneuraminidase associated with bacteriophage particles”. Journal of Virology 43 (2): 697–704. (August 1982). PMC 256172. PMID 7109038. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC256172/. 
  5. ^ “Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins”. Journal of Virology 63 (10): 4409–16. (October 1989). PMC 251059. PMID 2778882. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC251059/. 
  6. ^ “Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide”. Journal of Virology 55 (2): 374–8. (August 1985). PMC 254943. PMID 3894684. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC254943/. 
  7. ^ “Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase”. The Biochemical Journal 278 ( Pt 1): 311–2. (August 1991). doi:10.1042/bj2780311. PMC 1151486. PMID 1883340. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1151486/. 

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