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La timidilato sintasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione:
- 5,10-metilentetraidrofolato + dUMP ⇄ diidrofolato + dTMP
Bibliografia
- Blakley, R.L., The biosynthesis of thymidylic acid. IV. Further studies on thymidylate synthase, in J. Biol. Chem., vol. 238, 1963, pp. 2113–2118.
- Lockshin, A., Moran, R.G. and Danenberg, P.V., Thymidylate synthetase purified to homogeneity from human leukemic cells, in Proc. Natl. Acad. Sci. USA, vol. 76, 1979, pp. 750–754, Entrez PubMed 34155.
- Slavik, K. and Slavikova, V., Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography, in Methods Enzymol., vol. 66, 1980, pp. 709–723, Entrez PubMed 6990200.
- Wahba, A.J. and Friedkin, M., The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli, in J. Biol. Chem., vol. 237, 1962, pp. 3794–3801.
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