It begins in the Mount Dall and Yentna glacier systems and flows southeast to the Susitna River 2 miles (3.2 km) north of Susitna. The river system (including upstream tributaries) is about 100 miles (160 km) long.
Lake Creek just about 8 miles down river from Bottle Creek. Major fishing area: kings, reds, silvers. Winter sports, hunting.
Moose Creek, Indian Creek, Fish lakes Creek, Hewitt Creek, Malone's Slough, Donkey Creek, Johnson Creek, Clearwater Creek, Rich Creek, Flag Creek, Delta Creek, Fourth of July Creek, & Kichatna River round out the rest of the main Yentna River Tributaries.