As of 2024[update] its enrollment is about 600 pupils.
History
Like most public schools in Mississippi, Yazoo City High School was segregated until the 1960s. Yazoo City High School was historically an all-white school, while Blacks attended Yazoo High School #2.
^Dixon, Nathaniel (1 May 2024). "Dr. Sharon Brown - Yazoo City High School Principal, 2024-2025". Mississippi Achievement School District. Retrieved 7 May 2024. The Mississippi Achievement School District celebrates the appointment of Dr. Sharon Brown as the new Principal for Yazoo City High School, 2024-2025.