User talk:Cacycle/Archive 06Drug StructuresHi, do you know why it is that some pages such as methylphenidate only show the 3D structure for the drug, even though the chembox has a 2D structure link in there? The 3D structures look pretty, but really the 2D structure is more important in my opinion as its very difficult for someone who doesn't know what the structure of the drug looks like, to interpret a 3D structure where bits of the molecule are hidden away behind other bits.
Also I don't suppose you would mind drawing a new structure for mesocarb? I put a png image in there but really it should be replaced with an svg, the thing is though mesocarb has a weird aromatic ring in the middle which looks like the true structure is actually a hybrid of a bunch of resonance contributors, and I'm really not sure what the best way of drawing the structure is. I drew it with permanent charges on some of the atoms so they all have the right number of bonds, but I don't feel thats really a satisfactory representation and it would be good for someone who's a bit more specialised in chemistry to take a look at it.Meodipt 01:59, 19 October 2007 (UTC)
ThanksThanks for all your work adding and creating pages for molecules, it has been a great help to budding organic chem majors everywhere!!!! —Preceding unsigned comment added by 136.167.215.51 (talk) 04:17, 22 October 2007 (UTC) Thanks for your efforts regarding the List of people who have taken psychedelic drugs. I agree that the list could have been better sourced, but it was not nearly as bad as the others make it out to be. Deleting it all together was a mistake, removing unsourced entries is a much better route.C8755 (talk) 22:00, 3 January 2008 (UTC) Here are a few updates in the realm of WikiProject Pharmacology:
Dr. Cash 22:06, 31 October 2007 (UTC) Replaceable fair use Image:Rhodopsin in the membrane.pngThanks for uploading Image:Rhodopsin in the membrane.png. I noticed the 'image' page specifies that the image is being used under fair use, but its use in Wikipedia articles fails our first fair use criterion in that it illustrates a subject for which a freely licensed image could reasonably be found or created that provides substantially the same information. If you believe this image is not replaceable, please:
Alternatively, you can also choose to replace the fair use image by finding a freely licensed image of its subject, requesting that the copyright holder release this (or a similar) image under a free license, or by taking a picture of it yourself. If you have uploaded other fair use media, consider checking that you have specified how these images fully satisfy our fair use criteria. You can find a list of 'image' pages you have edited by clicking on this link. Note that even if you follow steps 1 and 2 above, fair use images which could be replaced by free-licensed alternatives will be deleted 2 days after this notification (7 days if not used in an article), per our Fair Use policy. If you have any questions please ask them at the Media copyright questions page. Thank you. —Remember the dot (talk) 03:46, 1 November 2007 (UTC) The RickK Anti-Vandalism Barnstar
I am concerned by your restoration of this article, about which considerable BLP concerns have been raised. Wikipedia:Articles for deletion/List of people who have taken psychedelic drugs seems to me a valid AFD. Rather than restoring it, I think you should raise the matter at deletion review. WjBscribe 20:56, 9 November 2007 (UTC)
The list was not adequately referenced - it was a very shabby effort. The sources were hearsay in some cases, and none contained the context of the drug use. You cannot just lump together those who may have used such drugs once with those that make regular use and promote such use. The context of each entry's drug use would need to be made clear and everything sourced to the highest standards. I strongly advise that if this list is wanted, it be recreated from scratch with proper attention to given each entry context and sourcing. If you want to challenge the deletion, DRV is available, but there is now considerable Community (and ArbCom) support for the deletion of articles as incompatible with BLP as that one. WjBscribe 22:06, 9 November 2007 (UTC)
AfD nomination of List of people who have taken psychedelic drugsAn article that you have been involved in editing, List of people who have taken psychedelic drugs, has been listed for deletion. If you are interested in the deletion discussion, please participate by adding your comments at Wikipedia:Articles for deletion/List of people who have taken psychedelic drugs (2nd nomination). Thank you. WjBscribe 21:12, 9 November 2007 (UTC) Stop wheel warringStop restoring List of people who have taken psychedelic drugs. It contains serious WP:BLP violations. You should talk about this with Ryan, or file at ArbCom if talking won't settle the matter. - Jehochman Talk 22:14, 9 November 2007 (UTC) Aspartame structure photoThe section of the aspartame molecule +H3N should be +H2N instead. Counting up your H atoms goes over the known amount in the molecule. Nevermind. I've found the alternate forms.Blackdakhma 16:14, 11 November 2007 (UTC)
Hi, I found another stimulant that is a mesoionic sydnone imine. I don't suppose you would mind drawing a structure for it? Seeing as your last one looked so nice I thought it would be better for you to do it than me! Meodipt (talk) 11:29, 17 November 2007 (UTC)
Sulfonic acidHi. Re the unstable / hypothetical! Have you any references for inorganic sulfonates or the acid? I would like to add this to the list of sulfur oxoacids, but none of the standard texts mentions either the acid or a salt. Axiosaurus (talk) 17:43, 22 November 2007 (UTC)
Thanks. Acids like sulfurous, sulfonic and sulfoxylic which cannot be detected in aqueous solution, but have been quoted historically are a bit of a problem to describe. Obviously the chemists weasel word "hypothetical" doesn't go down too well. Personally I am not to keen on unstable either, but it is a good fix until someone comes up with something better.Cheers.Axiosaurus (talk) 09:18, 23 November 2007 (UTC) wikiEd and RETFDoes wikiEd check for typos inside of links and template calls? MaxSem(Han shot first!) 19:02, 28 November 2007 (UTC)
2C (psychedelics)I don't see how the mini-structures from the article 2C (psychedelics) are "NOT the 2D structure of the compound" or are unnacceptable. I have checked through them, they all seem to be correct. Please explain why you removed them. --Use the force (Talk * Contribs) 22:26, 28 November 2007 (UTC)
Alright, so would it be fine it these included the full 2-D structure? --Use the force (Talk * Contribs) 13:22, 29 November 2007 (UTC)
LSA (ergine)Hi there. I'd like to add to the dispute over the psychoactivity or lack thereof of LSA. I note that you have stated that LSA is not hallucinogenic, and thus cannot be the active component of plants such as Hawaiian Baby Woodrose, Morning Glory and so on. However I believe that you may be mistaken. In TIHKAL, which is obviously accepted as the primary source in these matters, Shulgin states that LSA is not hallucinogenic at doses up to 2 milligrams. Other sources suggest that LSA may be active at larger doses. In "Pfaff RC, Huang X, Marona-Lewicka D, Oberlender R, Nichols DE. Lysergamides revisited. NIDA Research Monograph. 1994;146:52-73.", Nichols states that LSA has a relative potency of "3" (where LSD is "100"). This suggests that LSA may be active at ~33x the dose required for LSD, which would give an active dose of around 8.25mg. This is far enough above the dose range tested in TIHKAL to explain why a 2mg dose would have been dismissed as inactive, but still easily potent enough to be the active component in these plants. I would also note that LSA is considered to be the active component of Argyreia nervosa in the most recent literature available, although admittedly the authors seem unsure of this. Anyway my point is really that there just hasn't been enough research done to dismiss LSA as being inactive, and in the absence of any other suggested active components of these plants, LSA still seems the most likely contender. Meodipt 10:08, 2 December 2007 (UTC)
I did read Mixing the Kykeon, and I agree it does seem that there is a lack of evidence of hallucinogenic effects with LSA. However from a quick look around the scientific literature, LSA just doesn't seem to have been that thoroughly tested, and in vitro studies have shown LSA to be a 5HT2A agonist in isolated tissues. I'm just wondering if maybe LSA wasn't tested at a high enough dose to yield the psychadelic effects, there are several compounds where this is the case, i.e. EBDB ("Ethyl-J") was dismissed by Shulgin as being inactive when he tested it for PIHKAL, but subsequent recreational users have taken it at higher doses and found it to be quite active. Similarly Shulgin notes in TIHKAL that methysergide is hallucinogenic at 20mg, but if it was only ever tested at the clinical antimigraine dose of 2mg then you would never suspect it might be hallucinogenic. However I will conceed that these plants do not seem to have been fully analysed and there may be other active compounds in them - one paper I found on PubMed reported finding the monoethyl compound LAE-32 in Argyreia nervosa, so that does seem like another likely candidate as it is known to be active. Anyway I prefer working on new pages for compounds that don't have one yet so I'll leave this debate up to you guys! Meodipt 23:03, 2 December 2007 (UTC) Is thujone a toxin? Google agrees: thujone neurotoxin... GregorB (talk) 23:41, 8 December 2007 (UTC)
do I need copyright permission for your images?Dear Cacycle, I have used structural formulae of nitrogenous bases (C, T and U) you posted on Wikimedia to create an illustration for an encyclopedia article I am writing for Encyclopedia of Life Sciences (published by John Wiley & Sons). It is my understanding that, according to http://en.wikipedia.org/wiki/GNU_Free_Documentation_License, I am allowed to use and modify these images and they to publish the result. Please let me know if this is not the case for any reason. GFDL stipulates that the "original document should also be provided". Will a reference to Wikimedia suffice to meet this requirement? Many thanks in advance. Lev Yampolsky Department of Biological Sciences East Tennessee State University —Preceding unsigned comment added by L Yampolsky (talk • contribs) 04:58, 17 December 2007 (UTC)
I'm sorry Image:Bupropion.svg was incorrect; thanks for telling me. I tried to make it as similar to Image:Bupropion.png as possible, though I now see from Image:Bupropion_chemical_structure.png that the circle was actually just oxygen, which I didn't realize. Superm401 - Talk 05:18, 21 December 2007 (UTC) Article Deletion ProposalsI'm not sure why you want to delete my documents posted here: http://en.wikipedia.org/wiki/User:Nuklear I have removed all the tags that index them to other files. I dont think these are suitable to post in mainstream journals. I might be wrong about that but can you suggest which publishers would be interested in my work? At first I wanted to make the references easy to hotlink and the editing is easier to do than on my homepage: www.hochemicals.co.uk My homepage only allows for one page, large page border, and very slow at editing. My main motivation for wikipedia then was ease of use, and also sharing my expert knowledge in CNS research with a more general audience of readers who are obviously interested in my work. Clearly, it does not help with ones mental organization and physical communication just to do reading; In addition to this it is necessary to do some writing. These documents are essays of what I have learnt over the past decade in CNS research and development. I have stripped the files of all synthetic data as people were at one time wrongly getting the impression that I was writing how-to information concerning the making of these drugs. This is not that convincing though since non-qualified individuals are more likely to select target drugs such as MDMA and methamphetamine which are genuine recreational street-drugs, than pharmaceuticals which can be sold to pharmaceutical distributors and wholesalers. Wikipedia uses very unique computer coding. When I have tried to copy & paste these documents to other websites I get all of the coding regurgitated but not the same appearance as here. For example the reference tags: [1] and making words italic. Please can you tell me where I can move my pages to where I can copy & paste the info. and get it's appearance looking the same as on this website? I'm not necessarily that worried about having to pay some money to do so. I just dont want it looking disguisting after I remove it though. That is probably the chief underlying reason why they have not already been removed. I understand that wikipedia has been reasonable to me and has allowed me time to respond appropriately and not just deleted my content without sufficient notification. This is an example of what copy & paste looks like on google groups: http://groups.google.com/group/hochemicals/web/sndri Interestingly, the reference numbers link back to wikipedia instead of to the bottom of the page. Hence, significant and timewasting editing appears necessary to get the articles into an appropriate format. Do you have any ideas?
Searching toolHi, I thought you might be able to help on this one. Shannon bohle (talk · contribs) has been trying to write an extension that will rapidly search for the name of an article in a series of search engines. At the moment she is using separate templates for each article (e.g. {{Research guide Watson}}), which I think is cumbersome and prone to WP:DIRECTORY problems. I'm not good enough with JavaScript to sort this one out. Specifically, for this to work we'd have to pass the page title as an argument to a script that will parse it into the search engine's format. Would you be able to lend a hand? JFW | T@lk 06:57, 22 January 2008 (UTC)
Ref tags on wikEdWhen you have a moment, please see my query. --NigelG (or Ndsg) | Talk 10:19, 22 January 2008 (UTC)
I'm glad you're editing on MSGI hope you don't become the target of fringe vandalism like I was. I'll watch your talk page just in case. Cool Hand Luke 21:13, 26 January 2008 (UTC) Undid your Resvertrol deletionHi Cacycle, I was concerned to see you deleted a portion of tests regarding supplementation, and simply left this as part of your edit: "A number of companies have been created during the past 18 months with no previous experience in supplement manufacture to take advantage of resveratrol's popularity." It doesn't sound professional, and no references are given for it as well. I think we can edit the tests a bit to reflect current tests done on supplements and made available to the public, but not delete this information altogether. I have seen wine lists mentioned as well as other lists. I presume if you would agree to limit the Resveratrol to information on the molecule, we may do away with the "Supplement" of that is more appropiate. send me a post on this. thanks Mabidex
Hi, I see you tweaked the category description to be "transparent materials used in optics", and accordingly reverted my edits that added the category on Polyvinyl chloride, Insulin, and Silicone. However, by design and by preference, this new category was not intended to be limited to materials used in optics. There are several reasons. The most natural interpretation by lay readers of the phrase "transparent materials" is one that does not exclude non-optic materials. Whether a transparent material is used in optics is, I think, a secondary consideration. There is already Category:Optical materials for that particular field of application. Conflating a field of application with a physical property seems undesirable. Keeping separate categories by physical property and by field of application is more logical and more flexible because the intersections of these categories — and of potentially multiple additional unforeseen categories — can be freely constructed by the reader (e.g. using catint on the toolserver), rather than being limited to whatever predetermined category intersections we come up with now. I also think the original category is manageable and well-defined, with the proviso that there is an unwritten restriction which I had in mind of solid or semi-solid transparent materials, and which I had intended to add to the category description. I have not reverted your change to the category description or the materials articles mentioned. I think it is worth discussing this with you, and I would be interested to hear your thoughts. Perhaps you could reply here to keep the thread of conversation in one place. Thanks, - Neparis (talk) 06:53, 6 February 2008 (UTC)
(outdent) Hang on please regarding a CfD. I think the category can avoid being overly broad without limiting it to a particular field of application (which would make it a subcategory and possibly redundant to Category:Optical materials). I have in mind everyday materials that are likely to be familiar to lay readers, such as the transparent plastics and common minerals, rather than chemical compounds that are mostly likely to be unknown to lay readers. - Neparis (talk) 07:19, 6 February 2008 (UTC)
wikEdStrangeSpaces(Moved to wikEd talk) Regrading psilocybin molecule(s)Hey Cacycle I think the psilocybin molecule is wrong. I'm not a chemist, but why is the the oxygen bonded to the phosphorus a anion? Also why is the nitrogen a cation? Lastly the same nitrogen cation should not have a hydrogen bonded to it. It already used up it's two hydrogens on the two methyls didn't it?
css gadgetHi Prodego, I was just surprised by a the green-on-black layout of Wikipedia and I found the gadget checked in my preferences. Maybe I had it selected at some point in the past? Anyway, I see that it is only a test, but please could we discuss changes or additions on Wikipedia_talk:Gadget, MediaWiki_talk:Gadgets-definition, or Wikipedia:Gadget_proposals (or at least leave a note about planned changes). Thanks, Сасусlе 01:19, 11 February 2008 (UTC)
CategorisationHi Cacycle. I made a page for the CRF-1 antagonist antalarmin but have no idea what category it should go under, do you have any ideas? CRF antagonists are quite a significant field of research at the moment and antalarmin is the most widely recognised drug of this class so I thought it definitely needed a wikipedia page, but there don't seem to be many other pages I can link it to so its pretty much an orphan page right now! Meodipt (talk) 00:24, 18 February 2008 (UTC)
Ok did that too. Have a look and see if you're happy with how its all organised. Meodipt (talk) 03:42, 18 February 2008 (UTC) Speedy deletion of Image:Anisole chemical structure.pngA tag has been placed on Image:Anisole chemical structure.png requesting that it be speedily deleted from Wikipedia. This has been done under section I1 of the criteria for speedy deletion, because the image is redundant copy (all pixels the same or scaled down) of an image in the same file format, which is on Wikipedia (not on Commons), and all inward links have been updated. If you think that this notice was placed here in error, you may contest the deletion by adding ArsoleHello, why did revert the isoelectronic wording? --Lordy Why Have You Foresaken Me (talk) 09:16, 29 February 2008 (UTC)
psilocybin not an alkaloidwow you actually really cleared this up for me. thankyou, there are alot of people very confused on this subjuect, me including. thanks 72.66.243.238 (talk) 14:58, 4 March 2008 (UTC) Hi Cacycle. I think it was a good idea to create such templates on commons. In my opinion erroneous images such as this or low quality images that were replaced such as this should not just be tagged. IMHO they should be deleted after a while (in order to allow the uploader to give a feedback), because they are of no more use and categories can be kept clean this way. You might also have a look at this discussion. I emphasize that it is not my intention to get good quality PNG structures deleted such as the ones contributed by Ben. --Leyo 20:26, 4 March 2008 (UTC)
The low quality structures are included in the Category:Quality chemical diagrams. For me as a non-native English speaker, the name of the category suggests that high quality images are inside. If you agree, the name of the category might be changed. --Leyo 21:20, 23 March 2008 (UTC)
Delta opioid receptorsHi Cacycle. I removed the stuff saying that delta opioid receptors mediate the hallucinogenic effects of pentazocine and are activated by salvinorin A, as it was wrong - it is the kappa opioid receptor that does this! Common mistake, but the delta and kappa receptors are quite different! Meodipt (talk) 22:47, 21 March 2008 (UTC)
Awards Center NewsletterI'm pleased to announce that the Awards Center will be getting its own newsletter shortly. If you want to receive the WP:AWC newsletter, put your name here. --Sharkface217 20:42, 30 March 2008 (UTC) Flag IconsI reverted your removal of flag icons on the basis of WP:FLAGS#Appropriate_use. If you disagree, then please can you discuss it on the talk page before doing any further removals of flag icons. Thank you. Olana North (talk) 09:58, 2 April 2008 (UTC)
Tricarballic acidI was wondering why you moved this article to a new name, propanetricarboxylic acid? Neither name is official, we are under no pressure to use either. And a redirect from your favorite name would have sufficed to accomplish your goal. I can check here for your response. thanks, --Smokefoot (talk) 12:33, 3 April 2008 (UTC)
wikEdDiffJust a heads-up - I've added wikEdDiff as a gadget since it's useful even without wikEd. --Random832 (contribs) 14:36, 3 April 2008 (UTC)
Federation of American Societies for Experimental BiologyHello, Cacycle. You have new messages at Rjd0060's talk page.
You can remove this notice at any time by removing the {{Talkback}} or {{Tb}} template.
vandelthis guys a vandel 217.199.117.106 http://en.wikipedia.org/wiki/Special:Contributions/217.199.117.106 Alaskan assassin (talk) 01:04, 16 April 2008 (UTC) bureaucracyaddsection-plus was discussed in January; it wasn't added until now because it wasn't needed. --Random832 (contribs) 01:08, 23 April 2008 (UTC)
Stop trying to create bureaucracy for its own sakeWhen you claim that the fact that people object to your bureaucratic process is evidence of a need for an even more annoying process, you have a problem. --Random832 (contribs) 07:00, 26 April 2008 (UTC)
Thank you! Thank you! Thank you!For the life of me, I couldn't figure out how to use my monobook. I recently discovered my gadgets tab. A few checks and my Wiki time improved hundreds of percent! We should have a Wikipedia improvement of the year award. My vote would go to Wikipedia:Gadget. Thank you! GregManninLB (talk) 15:23, 26 April 2008 (UTC)
Conclusion: Image placeholders centralized discussionHi. I'm sending this to you because you participated in the Centralized discussion on image placeholders that ended on 23 April. That discussion must produce a conclusion. We originally asked "Should the addition of this box [example right] be allowed? Does the placeholder system and graphic image need to be improved to satisfy policies and guidelines for inclusion? Is it appropriate to some kinds of biographies, but not to others?" (See introduction). Conclusions to centralized discussions are either marked as 'policy', 'guideline', 'endorsed', 'rejected', 'no consensus', or 'no change' etc. We should now decide for this discussion. Please read and approve or disapprove the section here: Conclusion --Kleinzach (talk) 11:06, 30 April 2008 (UTC) Please note this message conforms to WP:CANVASSING and has not been sent to anyone has not already participated in the centralized discussion. Opioids templateHi Cacycle. An enthusiastic anonymous contributor has expanded the opioids template somewhat and it is now rather messy. They have added several sections including a "components of opium" section at the bottom including all the other alkaloids from the poppy, plus plant fats etc. I feel this is inappropriate and that the "opioids" template should be restricted to drugs which bind to opioid receptors, and the "components of opium" should be split into its own template, with a link from the opium page. However I'm not sure how to do this exactly and I don't want to mess the template up, I don't suppose you would mind taking a look at it? There are a few inaccuracies in their categorisations as well which I will fix up when I get time, but splitting the templates is a bit beyond my expertise. Meodipt (talk) 02:46, 3 May 2008 (UTC) Hmm after looking at it more closely I'm tempted to just revert the changes, as much of what they have done is just plain wrong! However they have clearly put a lot of work into it...what are your thoughts on this? Meodipt (talk) 03:14, 3 May 2008 (UTC)
Ok I have split out "components of opium" as a seperate template, how do I collapse it? I will then get onto trying to resort the opioid compounds into a more sensible arrangement. Meodipt (talk) 05:40, 3 May 2008 (UTC) Right I have done my best for now, the "components of opium" template needs attention from someone who knows how to edit templates properly though as I couldn't get it to collapse. Still not sure if the opioids are all categorised properly but I'll have another look when I got time, need to get back to my uni essays for now! Meodipt (talk) 06:00, 3 May 2008 (UTC)
Hypnotics and Sedatives templateHi Cacycle. There seems to be a problem with this template, it appears ok and all the links work, but when I try to edit it then it says that there is no such page and asks if I want to start a new one, any idea what is wrong? Meodipt (talk) 09:41, 6 May 2008 (UTC)
Ok I fixed it, not sure what was wrong but managed to find a link to the history and revert to an earlier version that didn't have the bug. Meodipt (talk) 12:16, 6 May 2008 (UTC)
Cacycle, I think I may have treaded on your toes with regard to the above page (sorry). I replaced the .png image with a .svg image which you had in effect already reverted. In this regard can you see my comments on the talk page.[[3]] - thanks Quantockgoblin (talk) 01:18, 8 May 2008 (UTC)
Lowercase i in PiHKAL and TiHKALHi there, Yesterday, you were reverting edits I was making to some of the tryptamines listed in TiHKAL. A quick look at your discussion page assures me that (like myself) you have an interest in psychedelics. I assure you, the lowercase "i" in the titles of the books PiHKAL and TiHKAL is intentional. Not just in the abbreviations, but in the full titles as well. The books themselves have this punctuation, if you'll take a glance at the cover artwork, or any mention of the titles within the books. It is also for this reason that the word "And" in the titles of both books is capitalized. Normally, the rules of English would suggest that "And", being a minor word in a title, should be lowercase. However, Alexander and Ann Shulgin specifically made it capitalized to draw more attention to the lowercase "i". The punctuation I've outlined for the titles of these two books is widely accepted. In fact, the titles of the articles themselves also have the lowercase "i". Swamilive (talk) 14:05, 3 June 2008 (UTC)
importScriptHi, I changed some of the installation instructions to use importScript. The reason is as follows: "use of write/writeln after the document is loaded can break, and requires blanking the entire page. onload handlers _should_ be getting run just before the completion of the <body> tag, but presumably there are mysterious circumstances where it's getting triggered late, or something." --TheDJ (talk • contribs) 19:08, 3 June 2008 (UTC)
Thank youThank you for the vote of confidence. I appreciate that. Someone was bold and reduced the protection on Wikipedia:Upload. I've cleaned up the page. I hope others find the page easier to understand. That was an ordeal. I can barely keep my eyes open. I gotta get some sleep! See ya around. The Transhumanist 14:17, 7 June 2008 (UTC) editing your editing summariesI am moving the paragraph that you wrote here from its current location (between "oppose" and "neutral") to "support." If I am wrong then just revert me (being careful to revert only this edit and not the 4 before that). Thank you. 69.140.152.55 (talk) 13:31, 9 June 2008 (UTC)
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