UNC93A
Protein-coding gene in the species Homo sapiens
Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene .[ 5]
Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.[ 6] [ 7] It belongs to the atypical SLCs that was recently listed.[ 6] It is therefore presumed that UNC93A is a transporter protein.
UNC93A is closely related to UNC93B1 and MFSD11 .[ 8] [ 9]
UNC93A is affected by amino acid deprivation in cell cortex cultures[ 7] [ 8] and starvation in in vivo samples.[ 8]
It is expressed in neurons, with staining close to the plasma membrane.[ 8]
Read also [ 10] [ 11] for functional studies in C.elegans.
For you who are interested to read more about Unc93A in different species, see: [ 12]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000112494 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067049 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: Unc-93 homolog A (C. elegans)" .
^ a b Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences . 38 (3): 305–315. doi :10.1016/j.tips.2016.11.008 . PMID 27939446 .
^ a b Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression" . Open Biology . 7 (9): 170142. doi :10.1098/rsob.170142 . PMC 5627054 . PMID 28878041 .
^ a b c d Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice" . Frontiers in Molecular Neuroscience . 10 : 351. doi :10.3389/fnmol.2017.00351 . PMC 5671512 . PMID 29163028 .
^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis" . PLOS ONE . 11 (6): e0156912. Bibcode :2016PLoSO..1156912P . doi :10.1371/journal.pone.0156912 . PMC 4896477 . PMID 27272503 .
^ Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction" . The Journal of Cell Biology . 117 (1): 143–55. doi :10.1083/jcb.117.1.143 . PMC 2289394 . PMID 1313436 .
^ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans" . The Journal of Neuroscience . 23 (27): 9133–45. doi :10.1523/JNEUROSCI.23-27-09133.2003 . PMC 6740817 . PMID 14534247 .
^ Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A" . Frontiers in Cell and Developmental Biology . 8 : 580291. doi :10.3389/fcell.2020.580291 . ISSN 2296-634X . PMC 7591606 . PMID 33163493 .
Further reading