Cloyd made his major-league debut on August 29, 2012, replacing Cole Hamels, who was ill.[1] Cloyd pitched six innings, allowing three runs on seven hits. Cloyd got his first MLB win vs. the Reds, giving up 1 run in 7 innings. Cloyd made 11 starts and 2 relief appearances for the Phillies in 2013, going 2–7 with a 6.56 ERA.[5]
Cleveland Indians
On October 2, 2013, Cloyd was designated for assignment and claimed by the Cleveland Indians. To make room on the 40-man roster, lefty Clay Rapada was designated for assignment.[6] The Indians then designated him for assignment on November 25.[7] On December 2, Cloyd was non-tendered by the Indians, making him a free agent.[8] He was re-signed to a minor league deal on December 13. On July 30, 2014, Cloyd threw a no hitter for the Columbus Clippers of the International League in a 13–0 win against the Louisville Bats.[9]
On February 1, 2016, Cloyd signed a minor league contract with the New York Yankees.[11] He made 4 appearances (3 starts) for the Triple–A Scranton/Wilkes-Barre RailRiders, logging a 1.37 ERA with 17 strikeouts across 19+2⁄3 innings. In May 2016, Cloyd underwent Tommy John surgery and missed nearly all of the 2016 season.[12] He elected free agency following the season on November 7.[13]
On May 11, 2017, Cloyd had his contract purchased by the Seattle Mariners and was assigned to the Triple-A Tacoma Rainiers. He was called up on June 2, but did not pitch until he appeared in relief against the Toronto Blue Jays on June 9. On June 21, Cloyd was designated for assignment. He spent the remainder of the year with Tacoma, registering a 5.67 ERA with 48 strikeouts across 19 games (14 starts). Cloyd elected free agency following the season on November 6.[14]
Miami Marlins
On January 12, 2018, Cloyd signed a minor league deal with the Miami Marlins.[15] He had his contract purchased on April 8. In 7 games for the Marlins, Cloyd struggled to an 8.66 ERA with 13 strikeouts across 17+2⁄3 innings pitched. He was removed from the 40–man roster and sent outright to the Triple–A New Orleans Baby Cakes on October 12.[16] Cloyd rejected the assignment and elected free agency the same day.
Somerset Patriots (second stint)
On February 11, 2019, Cloyd signed a minor league contract with the Tampa Bay Rays that included an invite to Spring Training. He was released by the Rays organization on March 26.
On April 19, 2019, Cloyd's contract was purchased by the Seattle Mariners, and he was assigned to the Triple-ATacoma Rainiers.[18] In 15 games (13 starts) for the Rainiers, he compiled a 2–8 record and 7.43 ERA with 69 strikeouts across 66+2⁄3 innings pitched. Cloyd was released by the Mariners organization on July 15.[19]