Tricetin 3',4',5'-O-trimethyltransferase

Tricetin 3',4',5'-O-trimethyltransferase
Identifiers
EC no.	2.1.1.169
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Tricetin 3',4',5'-O-trimethyltransferase (EC 2.1.1.169, FOMT, TaOMT1, TaCOMT1, TaOMT2) is an enzyme with systematic name S-adenosyl-L-methionine:tricetin 3',4',5'-O-trimethyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

3 S-adenosyl-L-methionine + tricetin ${\displaystyle \rightleftharpoons }$ 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin (overall reaction)

(1a) S-adenosyl-L-methionine + tricetin ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 3'-O-methyltricetin

(1b) S-adenosyl-L-methionine + 3'-O-methyltricetin ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin

(1c) S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin

The enzyme from Triticum aestivum catalyses the sequential O-methylation of tricetin via 3'-O-methyltricetin, 3',5'-O-methyltricetin to 3',4',5'-O-trimethyltricetin.

References

1. Kornblatt JA, Zhou JM, Ibrahim RK (May 2008). "Structure-activity relationships of wheat flavone O-methyltransferase: a homodimer of convenience". The FEBS Journal. 275 (9): 2255–66. doi:10.1111/j.1742-4658.2008.06377.x. PMID 18397325.
2. Zhou JM, Gold ND, Martin VJ, Wollenweber E, Ibrahim RK (July 2006). "Sequential O-methylation of tricetin by a single gene product in wheat". Biochimica et Biophysica Acta (BBA) - General Subjects. 1760 (7): 1115–24. doi:10.1016/j.bbagen.2006.02.008. PMID 16730127.
3. Zhou JM, Seo YW, Ibrahim RK (April 2009). "Biochemical characterization of a putative wheat caffeic acid O-methyltransferase". Plant Physiology and Biochemistry. 47 (4): 322–6. doi:10.1016/j.plaphy.2008.11.011. PMID 19211254.

External links

• Tricetin+3',4',5'-O-trimethyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)