Tilorone

Tilorone
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth (tablets)
ATC code
Pharmacokinetic data
Bioavailability60%
Protein binding~80%
MetabolismNil
Elimination half-life48 hours
ExcretionFeces (70%), urine (9%)[1]
Identifiers
  • 2,7-Bis(2-diethylaminoethoxy)fluoren-9-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H34N2O3
Molar mass410.558 g·mol−1
3D model (JSmol)
  • CCN(CC)CCOc1ccc-2c(c1)C(=O)c3c2ccc(c3)OCCN(CC)CC
  • InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3 ☒N
  • Key:MPMFCABZENCRHV-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.[2] It is used as an antiviral drug in some countries which do not require double-blind placebo-controlled studies, including Russia. It is effective against Ebola virus in mice.[3] It shows activity against Eastern equine encephalitis and related viruses.[4]

Pharmacology

Tilorone activates the production of interferon.[2]

See also

References

  1. ^ "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in Russian). Retrieved 2 October 2016.
  2. ^ a b Stringfellow DA, Glasgow LA (August 1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrobial Agents and Chemotherapy. 2 (2): 73–78. doi:10.1128/aac.2.2.73. PMC 444270. PMID 4670490.
  3. ^ Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, et al. (February 2018). "Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection". Antimicrobial Agents and Chemotherapy. 62 (2). doi:10.1128/AAC.01711-17. PMC 5786809. PMID 29133569.
  4. ^ Ogorek TJ, Golden JE. Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses. Viruses. 2023 Feb 1;15(2):413. doi:10.3390/v15020413 PMID 36851628
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