Theresa M. Reineke

Theresa Marie Reineke
Born (1972-01-01) January 1, 1972 (age 53)
Alma materUniversity of Wisconsin–Eau Claire
Arizona State University
University of Michigan
Scientific career
InstitutionsUniversity of Minnesota
California Institute of Technology
ThesisMetal-organic porous frameworks designed from zinc(II), terbium(III), europium(III), and organic carboxylate building blocks (2000)
Doctoral advisorOmar M. Yaghi

Theresa M. Reineke (born January 1, 1972) is an American chemist and Distinguished McKnight University Professor at the University of Minnesota. She designs sustainable, environmentally friendly polymer-based delivery systems for targeted therapeutics. She is the associate editor of ACS Macro Letters.

Early life and education

Reineke earned her bachelor's degree at University of Wisconsin–Eau Claire.[1] She moved to Arizona State University for her graduate studies and earned a master's degree in 1998.[1][2] Reineke was a PhD student at the University of Michigan, where she was supervised by Michael O'Keeffe and Omar M. Yaghi.[1][3] She was awarded the Wirt and Mary Cornell Prize for Outstanding Graduate Research. Reineke joined the California Institute of Technology as an National Institutes of Health postdoctoral fellow in 2000.[1]

Research and career

Reineke joined the University of Minnesota in 2011. Her research group focus on the design, characterisation and functionalisation of macromolecular systems.[4][5] These macromolecules include biocompatible polymers that can deliver DNA for regenerative medicine as well as targeted therapeutic treatments.[4] She was made a Lloyd H. Reyerson Professor with tenure at the University of Minnesota in 2011.[1] Reineke has published over 140 papers.[6]

Nucleic acids can have an unparalleled specificity for targets inside a cell, but need to be compacted into nanostructures (polyplexes) that can enter cells.[7] Reineke designs polymer-based transportation systems for nucleic acids.[7] These polymer vehicles can improve the solubility and bioavailability of drugs.[8] These often incorporate carbohydrates, which have an affinity for polyplexes and are non-toxic.[7] She is a member of the University of Minnesota Centre for Sustainable Polymers, synthesising polymers from sustainable ingredients. The carbohydrate units within her polymer drug delivery systems are a widely available, renewable resource.[9] The sustainable polymers designed by Reineke include poly(ester-thioethers).[9]

Reineke used reversible addition−fragmentation chain-transfer polymerization for the synthesis of diblock terpolymers that can be used for targeted drug delivery.[10] She used spray dried dispersions of the polymer with the drug probucol.[11]

Reineke was made a University of Minnesota Distinguished McKnight University Professor in 2017.[1] She is the associate editor of ACS Macro Letters and on the Advisory Board of Biomacromolecules, Bioconjugate Chemistry and Polymer Chemistry.[1] She is a member of the American Chemical Society Polymer Division.[12] Her work has been supported by an National Science Foundation CAREER Award, a Sloan Research Fellowship, the National Institutes of Health and the National Academy of Sciences.[13]

Awards and honors

Patents

  • 2014 Monomers, polymers and articles containing the same from sugar derived compounds[25]
  • 2018 Isosorbide-based polymethacrylates[26]

References

  1. ^ a b c d e f g h i j "Dr. Theresa M. Reineke". The Reineke Group. Retrieved 2019-04-17.
  2. ^ "Nonviral Synthetic Polymers Promote Cellular and In Vivo Delivery of Therapeutic Genes and Editing Systems". Breakthrough Symposium. Retrieved 2019-04-17.
  3. ^ "Chemistry Tree – Theresa M. Reineke". academictree.org. Retrieved 2019-04-17.
  4. ^ a b "Research". The Reineke Group. Retrieved 2019-04-17.
  5. ^ Aldevron (2018-12-04), Theresa Reineke; Breakthrough Symposium Presenter, retrieved 2019-04-17
  6. ^ "Publications Archive - Page 2 of 2 - The Reineke Group". Retrieved 2023-10-13.
  7. ^ a b c "Nucleic Acid Delivery". The Reineke Group. Retrieved 2019-04-17.
  8. ^ Stanford, © Stanford University; Notice, California 94305 Copyright Complaints Trademark. "2019 Winter Talk (Theresa M. Reineke, University of Minnesota) | Stanford Polymer Collective". web.stanford.edu. Retrieved 2019-04-17.{{cite web}}: CS1 maint: numeric names: authors list (link)
  9. ^ a b "Sustainable Polymers". The Reineke Group. Retrieved 2019-04-17.
  10. ^ "Oral Drug Delivery". The Reineke Group. Retrieved 2019-04-17.
  11. ^ Tale, Swapnil; Purchel, Anatolii A.; Dalsin, Molly C.; Reineke, Theresa M. (2017-09-22). "Diblock Terpolymers Are Tunable and pH Responsive Vehicles To Increase Hydrophobic Drug Solubility for Oral Administration". Molecular Pharmaceutics. 14 (11): 4121–4127. doi:10.1021/acs.molpharmaceut.7b00458. ISSN 1543-8384. PMID 28937226.
  12. ^ "Reineke – address". old.polyacs.org. Retrieved 2019-04-17.
  13. ^ "Fellows Database | Alfred P. Sloan Foundation". sloan.org. Retrieved 2022-03-24.
  14. ^ "Faculty Awards". www.artsci.uc.edu. Retrieved 2019-04-17.
  15. ^ "Outstanding New Investigator Awards | ASGCT – American Society of Gene & Cell Therapy | ASGCT – American Society of Gene & Cell Therapy". www.asgct.org. Retrieved 2019-04-17.
  16. ^ "MP's Reineke receives Macro 2012 Lecture Award | IPRIME". iprime.umn.edu. Retrieved 2019-04-17.
  17. ^ "Theresa M. Reineke, Ph.D. COF-2038 – AIMBE". Retrieved 2019-04-17.
  18. ^ "Reineke selected 2016 Sara Evans Faculty Woman Scholar | Center for Sustainable Polymers". Retrieved 2019-04-17.
  19. ^ "Theresa Reinke, of IPrime's polymer group, receives Talyor Award for Distinguished Research | IPRIME". www.iprime.umn.edu. Retrieved 2019-04-17.
  20. ^ "Carl S. Marvel Award for Creative Polymer Chemistry". Division of Polymer Chemistry, Inc. 2017-11-28. Retrieved 2019-04-17.
  21. ^ "DuPont Nutrition & Health Honors 2018 Science Excellence and Microbiome Science Award Medalists – DuPont | Danisco". www.dupontnutritionandhealth.com. Retrieved 2019-04-17.
  22. ^ harva015 (2018-10-11). "Reineke honored with DuPont Nutrition & Health Science Excellence Medal". Department of Chemistry. Retrieved 2019-04-17.{{cite web}}: CS1 maint: numeric names: authors list (link)
  23. ^ harva015 (2018-02-22). "Professor Reineke named a 2018 POLY Fellow". Department of Chemistry. Retrieved 2019-04-17.{{cite web}}: CS1 maint: numeric names: authors list (link)
  24. ^ "News | MRSEC". mrsec.umn.edu. Retrieved 2019-04-17.
  25. ^ "US Patent for Monomers, polymers and articles containing the same from sugar derived compounds Patent (Patent # 9,505,778 issued November 29, 2016) – Justia Patents Search". patents.justia.com. Retrieved 2019-04-17.
  26. ^ "US Patent for Isosorbide-based polymethacrylates Patent (Patent # 9,988,393 issued June 5, 2018) – Justia Patents Search". patents.justia.com. Retrieved 2019-04-17.