Going into the game Harlequins had won all of their Premiership games, but fell to defeat in this their eleventh game to the team second in the table. As Twickenham had a capacity 82,000 crowd this game set a global rugby union attendance record for a regular-season club fixture.[6]
Pending developments with the COVID-19 pandemic, Big Game 13 was planned to be held in spring 2021.[8] The game never came to fruition and Harlequins would instead return to Twickenham twice the following season. Big Game 13 was the first time that Harlequins Women had played a Premier 15s match at Twickenham Stadium.[1]
Harlequins intended to play Big Game 14 during the normal festive period. However, due to industrial action they were forced to play their festive fixture against Bristol Bears at Twickenham Stoop and would instead move their round 19 match against Exeter Chiefs to Twickenham.[10] They would return to Twickenham the following month for their annual 'Big Summer Kick-Off' match