The Best Mysteries of Isaac Asimov is a collection of mystery short stories by American author Isaac Asimov. It was first published in hardcover by Doubleday in 1986, and in paperback by the Fawcett Crest imprint of Ballantine Books in September 1987.
The book contains thirty-one stories by Asimov, including fifteen featuring his fictional club of mystery solvers, the Black Widowers, nine of his Union Club mysteries, and seven others (one featuring his science fictional detective Wendell Urth and two featuring his boy detective Larry). Most were reprinted from mystery magazines.