Mizzell signed with the Baltimore Ravens as an undrafted free agent on May 5, 2017.[5] He was waived on September 2, 2017.[6]
Chicago Bears
On September 3, 2017, Mizzell was claimed off waivers by the Chicago Bears.[7]
On September 1, 2018, Mizzell was waived by the Bears and was signed to the practice squad the next day.[8][9] He was promoted to the active roster on November 3, 2018.[10] In his first game against the Buffalo Bills, Mizzell served as kick returner and also caught a pass for five yards.[11] On Thanksgiving Day, Mizzell scored his first NFL touchdown on a ten-yard reception from Chase Daniel against the Detroit Lions.[12] The following week against the New York Giants, Mizzell rushed three times for seven yards, caught two passes for sixteen yards, and returned two kicks for twenty-four yards.[13] He ended the 2018 season with nine carries for 16 yards and eight receptions for 78 yards and a touchdown.[14]
Before the 2019 season, Mizzell switched to wide receiver from running back; in conjunction with the position move, he changed his number from 33 to 11.[15] He was released during final roster cuts on August 31.[16]
New Orleans Saints
On September 1, 2019, Mizzell was signed to the New Orleans Saints practice squad.[17] He signed a reserve/future contract with the Saints on January 7, 2020.[18] He was waived on August 2, 2020.[19]
New York Giants
On November 17, 2020, Mizzell was signed to the Giants' practice squad.[20] He signed a reserve/future contract on January 4, 2021.[21] He was placed on injured reserve on July 23, 2021, with a hamstring injury. He was later waived on July 29.[22]
BC Lions
On April 18, 2022, Mizzell signed with the BC Lions of the Canadian Football League.[23] In 2023, Taquan Mizzell rushed for 773 Yards on 157 carries and 3 TDs for the Lions. He had an additional 291 Yards and 2 scores on 41 pass receptions.[24] After two years with the team, he was released on May 27, 2024.[25]