Tanshinone

Chemical structure of tanshinone I

Tanshinones are a class of chemical compounds. Examples include dihydrotanshinone, tanshinone I, or tanshinone IIA. These compounds are all naturally occurring and can all be isolated from Salvia miltiorrhiza.[1][2]

Dihydrotanshinone I has been reported to have cytotoxicity to a variety of tumor cells.[3]

Tanshinone I is anti-inflammatory, and modulates or prevents breast cancer metastasis by regulating adhesion molecules.[4]

Tanshinone IIA is anti-inflammatory, an antioxidant, and cytotoxic against a variety of cell lines.[5]

References

  1. ^ Lee WY, Cheung CC, Liu KW, et al. (May 2010). "Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells". J. Nat. Prod. 73 (5): 854–9. doi:10.1021/np900792p. PMID 20455578.
  2. ^ Yoon Y; Kim YO; Jeon WK; Park HJ; Sung HJ (December 1999). "Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line". J Ethnopharmacol. 68 (1–3): 121–7. doi:10.1016/S0378-8741(99)00059-8. PMID 10624871.
  3. ^ Bian, W; Chen, F; Bai, L; Zhang, P; Qin, W (2008). "Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo". Acta Biochimica et Biophysica Sinica. 40 (1): 1–6. doi:10.1111/j.1745-7270.2008.00370.x. PMID 18180848.
  4. ^ "Tanshinone I T5330". Sigma-Aldrich.
  5. ^ "Tanshinone IIA T4952". Sigma-Aldrich.